Oleifolioside A mediates caspase-independent human cervical carcinoma HeLa cell apoptosis involving nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG

Journal of Agricultural and Food Chemistry
Hai Yang YuJai-Heon Lee

Abstract

Apoptosis, the main type of programmed cell death, plays an essential role in a variety of biological events. Whereas "classical" apoptosis is dependent on caspase activation, caspase-independent death is increasingly recognized as an alternative pathway. To develop new anticancer agents, oleifolioside A was isolated from Dendropanax morbifera Leveille and the biochemical mechanisms of oleifolioside A-induced apoptosis in HeLa cells were investigated. Exposure to oleifolioside A resulted in caspase activation and typical features of apoptosis, although cell death was not prevented by caspase inhibition. Oleifolioside A treatment induced up-regulation of Bad, loss of mitochondrial membrane potential, nuclear relocation of mitochondrial factors, apoptosis-inducing factor (AIF), endonuclease G (EndoG), and apoptosis induction. This is the first report of anticancer activity of oleifolioside A, and nuclear translocation of AIF and EndoG in oleifolioside A-treated HeLa cells might represent an alternative death signaling pathway in the absence of caspase activity.

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Citations

Apr 29, 2014·Apoptosis : an International Journal on Programmed Cell Death·Eun-Ae KimTae-Jin Lee
Jul 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhenchang SunHaopeng Li
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Byoung Ok ChoIl Yun Jeong
Jan 23, 2018·Journal of Menopausal Medicine·Mijin KimBora Lee

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