Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of Gulf War Illness

Scientific Reports
Utsav JoshiLaila Abdullah

Abstract

There are nearly 250,000 Gulf War (GW) veterans who suffer from Gulf War Illness (GWI), a multi-symptom condition that remains untreatable. The main objective was to determine if targeting peroxisomal function could be of therapeutic value in GWI. We performed a pilot study that showed accumulation of very long chain fatty acids (VLCFA), which are metabolized in peroxisomes, in plasma from veterans with GWI. We then examined if targeting peroxisomal β-oxidation with oleoylethanolamide (OEA) restores these lipids to the normal levels and mitigates neuroinflammation and neurobehavioral deficits in a well-established mouse model of GWI. In GWI mice, treatment with OEA corresponded with cognitive benefits and reduced fatigue and disinhibition-like behavior in GWI mice. Biochemical and molecular analysis of the brain tissue showed reduced astroglia and microglia staining, decreased levels of chemokines and cytokines, and decreased NFκB phosphorylation. Treatment with OEA reduced accumulation of peroxisome specific VLCFA in the brains of GWI mice. These studies further support the translational value of targeting peroxisomes. We expect that OEA may be a potential therapy for treating neurobehavioral symptoms and the underlying lipid ...Continue Reading

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Citations

Oct 20, 2019·Military Medical Research·Jeremy E ChesterDrew A Helmer
Nov 10, 2020·Pharmacology & Therapeutics·Brandon DickeyAshok K Shetty
Jul 22, 2019·Brain, Behavior, and Immunity·Utsav JoshiLaila Abdullah
Jun 26, 2021·Pharmacology & Therapeutics·Ana C R Ribeiro, Laxmikant S Deshpande
Aug 2, 2021·Brain, Behavior, and Immunity·Joshua D BryantA Phillip West
Aug 15, 2021·Toxicology·Raghavan Pillai Raju, Alvin V Terry

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ELISA
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Software Mentioned

SPSS
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