PMID: 16522910Mar 9, 2006Paper

Olestra is associated with slight reductions in serum carotenoids but does not markedly influence serum fat-soluble vitamin concentrations

The American Journal of Clinical Nutrition
Marian L NeuhouserMark D Thornquist

Abstract

The 1996 Food and Drug Administration approval of the fat substitute olestra (sucrose polyester) called for active postmarketing surveillance because preapproval studies showed that olestra may lower circulating concentrations of fat-soluble nutrients such as vitamins and carotenoids. The objective of the Olestra Post-Marketing Surveillance Study was to examine whether customary consumption of olestra-containing savory snacks was associated with changes in serum fat-soluble vitamin and carotenoid concentrations among free-living persons in geographically and ethnically distinct US cities. Adults (n = 2535) and their children aged 12-17 y (n = 272) in Baltimore, Minneapolis, and San Diego attended clinic visits during which data were collected on diet, savory snack consumption, lifestyle, and anthropometric indexes. Blood samples were drawn to assay carotenoids and vitamins A, D, E, and K. Data and blood samples were collected both before and after the nationwide introduction of olestra. General estimating equations were used in multivariate-adjusted models that examined olestra's association with the specified serum nutrients. Compared with no intake, the top 2 tertiles of olestra use in adults were associated with circulating ...Continue Reading

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Citations

Nov 6, 2008·Expert Opinion on Drug Safety·Richard M Fleming
May 8, 2013·Bioscience, Biotechnology, and Biochemistry·Akihiko NagaoMegumi Hase
Aug 30, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Diying ShenLingyan Zhang
Sep 7, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan L McKimmieRichard B Weinberg

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