Oleuropein and hydroxytyrosol rich extracts from olive leaves attenuate liver injury and lipid metabolism disturbance in bisphenol A-treated rats

Food & Function
Asma MahmoudiSami Sayadi

Abstract

In the present study, we investigated the protective effects of oleuropein- and hydroxytyrosol-rich extracts obtained from olive leaves against bisphenol A (BPA)-induced hyperlipidemia and liver injury in male rats. For this purpose, four groups of male rats (8 per group) were used: control group (Control), rats treated with BPA, rats treated with both BPA and oleuropein (OLE-BPA), and rats treated with both BPA and hydroxytyrosol (HYT-BPA). After 60 days of treatment, the results obtained using the DXA technique showed that treatment with BPA (10 mg per kg b.w.) increased the body weight and adipose tissue mass in male rats. Moreover, plasma levels of triglycerides, total cholesterol, LDL-cholesterol, AST, ALT, LDH, and TNF-α increased. The immunohistochemical analysis revealed a significant increase in the expression of COX-2 and p53 and a decrease in the expression of Bcl-2 related to liver inflammation. Oral administration of oleuropein and hydroxytyrosol-rich extracts obtained from olive leaves at 16 mg kg-1 reduced both the body weight and adipose tissue mass. These extracts were able to ameliorate liver damage and improve the elevated levels of TG and liver enzymes of BPA-treated rats possibly through enhancing CAT and S...Continue Reading

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Citations

Nov 21, 2019·Phytotherapy Research : PTR·Javed AhamadJaved Ahmad
Nov 23, 2019·Archives of Physiology and Biochemistry·Yan LiuShandong Ye
Feb 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Di YangZhengquan Su
Oct 31, 2019·International Journal of Environmental Research and Public Health·Ren LinLihong Jia
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Emanuele MauriAlberto Rainer
Oct 31, 2021·Journal of Food Biochemistry·Masood Sadiq ButtMuhammad Rizwan

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