Oleuropein prevents ethanol-induced gastric ulcers via elevation of antioxidant enzyme activities in rats.

Journal of Physiology and Biochemistry
Masoud AlirezaeiArash Kheradmand

Abstract

Purified oleuropein from olive leaf extract has been shown to have antioxidant effects in our recent studies. Thus, the aim of this study was to assess the antioxidant abilities of oleuropein in comparison with ranitidine in ethanol-induced gastric damages via evaluation of ulcer index inhibition, antioxidant enzyme activities, and lipid peroxidation level. Fifty-six adult male Sprague-Dawley rats were divided into seven equal groups as follows: control group, ethanol group (absolute ethanol 1 ml/rat), oleuropein group (12 mg/kg), and oleuropein (6, 12, and 18 mg/kg) plus ethanol groups, as well as ranitidine (50 mg/kg) plus ethanol group. Pretreatment with oleuropein (12 and 18 mg/kg) significantly increased the ulcer index inhibition (percent), in comparison with oleuropein (6 mg/kg). Glutathione peroxidase (GPx) activity was significantly lower in the ethanol group when compared with the other groups whereas, treatment of rats with oleuropein (12 mg/kg) significantly increased glutathione content in gastric tissue when compared with the other groups, and lipid peroxidation was significantly reduced in the oleuropein- (12 and 18 mg/kg) and ranitidine-treated animals. Superoxide dismutase (SOD) and catalase (CAT) activities we...Continue Reading

References

Dec 1, 1992·Planta medica·M GonzalezI Osuna
Oct 1, 1991·Planta medica·A ZarzueloM P Utrilla
Jul 1, 1990·Journal of Neurochemistry·K V SubbaraoL C Ang
Sep 1, 1988·Critical Care Medicine·S M Smith, P R Kvietys
Feb 1, 1988·New York State Journal of Medicine·B E Bodner
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·H W Wahner, B L Riggs
Jan 1, 1985·Gastroenterology·F W LeungP H Guth
Aug 25, 1993·Molecular and Cellular Biochemistry·D Das, R K Banerjee
Aug 1, 1993·Inflammation·M Leirisalo-RepoH Repo
Jan 1, 1997·Free Radical Biology & Medicine·D DasR K Banerjee
Jun 24, 1998·Biochemical and Biophysical Research Communications·F VisioliC Galli
Feb 2, 1999·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·S N Elliott, J L Wallace
Nov 24, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·V Z LankinA I Kozachenko
Feb 21, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G E P De SouzaA R Zampronio
Oct 17, 2002·Journal of Agricultural and Food Chemistry·Caterina MannaVincenzo Zappia
Jan 17, 2003·The Journal of Biological Chemistry·Kaushik BiswasRanajit K Banerjee
Jan 22, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Piero Del BoccioDomenico Rotilio
Aug 11, 2004·The Journal of Nutritional Biochemistry·Caterina MannaVincenzo Zappia
Sep 20, 2005·Journal of Ethnopharmacology·Fehmi OdabasogluCavit Kazaz
Oct 21, 2005·Life Sciences·Hasan Fayadh Al-Azzawie, Mohamed-Saiel Saeed Alhamdani
Nov 28, 2006·Journal of Ethnopharmacology·Muriel Primon de BarrosSérgio Faloni de Andrade
Jan 16, 2007·Journal of Molecular and Cellular Cardiology·Ioanna AndreadouDimitrios Th Kremastinos
Jun 24, 2008·Journal of Andrology·Terry T Turner, Jeffrey J Lysiak
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Je-Hyuk LeeChoon-Sik Jeong
Feb 23, 2010·Regulatory Peptides·Arash KheradmandMahdi Birjandi
Mar 23, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J López-MirandaN Yiannakouris
Dec 21, 2010·Regulatory Peptides·Arash KheradmandMohammad Javad Tarrahi
Jun 24, 2011·Journal of Physiology and Biochemistry·Masoud AlirezaeiSaeed Nazifi

❮ Previous
Next ❯

Citations

Feb 20, 2016·The Journal of Physiological Sciences : JPS·Soheila PourkhodadadZahra Khanipour
May 24, 2014·Geriatrics & Gerontology International·Jale ÇobanMüjdat Uysal
Mar 30, 2016·The Journal of Physiological Sciences : JPS·Masoud AlirezaeiKatayoun Kiani
Jan 21, 2014·Biochimica Et Biophysica Acta·Sergio LopezFrancisco J G Muriana
Jun 24, 2014·Journal of Asian Natural Products Research·Ali Akbar NekooeianMohammad Bagher Khosravi
Apr 21, 2017·Food & Function·Maria Luisa CastejónCatalina Alarcón-de-la-Lastra
Feb 27, 2018·Journal of Dairy Science·Jeong-Hyun YooHae-Jeung Lee
Sep 25, 2020·International Journal of Radiation Biology·Fatemeh AmaniMohammad Hossein Mohammadi
Apr 20, 2020·Basic & Clinical Pharmacology & Toxicology·Amany Abdel-Mageed AlzokakyNahed A Raslan
Aug 22, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Fatime GeyikoğluMerve Sönmez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.