Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases

Archives of Neurology
R I MesholamR L Doty

Abstract

Olfactory deficits in Alzheimer's disease (AD) and idiopathic Parkinson's disease (PD) have been well established. To clarify and review the literature by evaluating the evidence for olfactory deficits in 3 olfactory domains, including odor identification, recognition, and detection threshold. A literature search of English-language studies of olfaction in AD, PD, and healthy controls was conducted via online databases (PsycInfo and MEDLINE) and reference lists from review articles. To meet selection criteria for meta-analysis, each study required a control group and complete and usable data. This review yielded 26 publications of olfactory identification, recognition, and/or detection threshold. Because of the inclusion of more than 1 relevant study of olfaction in several of these publications (eg, both identification and threshold assessed), 43 studies were ultimately appropriate for meta-analysis. Effect sizes were calculated for each study by expressing differences between patient and control group means in SD units (Cohen's d). Extremely large effect sizes were shown across all tasks in both AD and PD groups. Both between-group analyses using the Mann-Whitney U test and within-group analyses using Friedman 2-way analysis ...Continue Reading

Citations

Feb 6, 2014·Maturitas·Sophie BehrmanKlaus P Ebmeier
Jul 9, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christine SmolinerRainer Wirth
Nov 5, 2013·Multiple Sclerosis International·Felix SchmidtLutz Harms
Mar 7, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Samuel Weiss
May 16, 2003·Psychological Review·Richard J Stevenson, Robert A Boakes
Sep 14, 2000·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·M LarssonN L Pedersen
Dec 22, 2007·Neuro-Signals·Sarah M Kranick, John E Duda
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·R H McShaneA D Smith
Aug 27, 2005·BMC Neurology·Lianna S IshiharaCarol Brayne
Mar 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin G BathFrancis S Lee
Apr 5, 2008·Journal of Neuroinflammation·Xuesong ChenJonathan D Geiger
Jun 24, 2008·Experimental Aging Research·Robert S WilsonDavid A Bennett
Jul 10, 2008·PloS One·Jürgen KonczakHoward Poizner
Jan 14, 2009·Archives of Neurology·Matteo PardiniJordan Grafman
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel W WessonDonald A Wilson
Apr 24, 2010·Brain : a Journal of Neurology·Nicolaas I BohnenKirk A Frey
Aug 14, 2010·Current Gerontology and Geriatrics Research·A von GuntenE Kövari
Oct 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erica PeethumnongsinHui Zheng
Mar 23, 2011·Molecular Neurobiology·Daniel W WessonDonald A Wilson
May 26, 2011·PloS One·Felix Alexander SchmidtFranca Fleiner
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel W WessonDonald A Wilson
Oct 3, 2013·PloS One·Reynaldo Alvarado-MartínezFernando Peña-Ortega
Nov 10, 2013·PloS One·Stefan KurtenbachHermann Lübbert
Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Y SuzukiS H Jackson
Jun 21, 2013·Acta Neuropathologica·Iñaki-Carril MundiñanoMaria-Rosario Luquin
Sep 10, 2010·Harvard Review of Psychiatry·An D NguyenJames J Levitt
Dec 15, 2005·Neuroepidemiology·Robert S WilsonDavid A Bennett
Jul 14, 2009·Journal of Clinical Psychopharmacology·Latha Velayudhan, Simon Lovestone
Jun 12, 2003·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Holly James WesterveltGeoffrey Tremont
Sep 12, 2007·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Paul J MobergJohn E Duda
Oct 22, 2008·Journal of Clinical and Experimental Neuropsychology·Holly James WesterveltGeoffrey Tremont
Jan 11, 2012·Journal of Clinical and Experimental Neuropsychology·Céline BorgCatherine Thomas-Antérion
Aug 22, 2012·Journal of Clinical and Experimental Neuropsychology·Valentina ParmaUmberto Castiello
Jun 25, 2013·Journal of Clinical and Experimental Neuropsychology·Carla R SchubertDavid M Nondahl
Mar 8, 2011·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Iwona MakowskaKrystyna Rymarczyk
Apr 9, 2011·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Eike WehlingAstri J Lundervold
May 15, 2013·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Marta Zaffira ContiLuca Rozzini
Jul 14, 2009·Journal of Motor Behavior·Jürgen KonczakMatthias Maschke
Aug 9, 2013·Journal of Biomedical Science·Alessandro TonacciMaria Grazia Andreassi
Jan 30, 2007·Neuroreport·Fernando A BarriosJuan Fernandez-Ruiz
Jan 31, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lindsey A CzarneckiJohn P McGann
Apr 6, 2011·Current Opinion in Neurology·Lama M Chahine, Matthew B Stern

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Neurosciences
Arie S MobleyCharles A Greer
Archives of Otolaryngology--head & Neck Surgery
Andreas F P TemmelThomas Hummel
Journal of the American Dietetic Association
Richard D Mattes
Archives of Otolaryngology--head & Neck Surgery
G A GatesR B D'Agostino
© 2021 Meta ULC. All rights reserved