Olfaction in Parkin carriers in Chinese patients with Parkinson disease

Brain and Behavior
Ying WangYi-Min Sun

Abstract

Olfactory identification was reported to be better among PD (Parkinson disease) patients with Parkin mutations, but previous studies didn't eliminate the interference of other PD related genes on olfaction, and whether olfaction of Parkin mutations patients was better in Chinese population was still unknown. To assess olfaction function among PD patients with Parkin mutations in Chinese population. A total of 226 PD patients with a positive family history or an early-onset age (<50 years) were enrolled for genetic testing of PD related genes by target sequencing and multiple ligation-dependent probe amplification. The clinical data including olfactory function test were investigated. Linear regression was performed to adjust for the covariates between all groups. There were 68 patients found having a negative result in PD genetic testing and 43 patients carrying homozygous or compound heterozygous Parkin mutations. Among them, 49 PD panel negative patients and 33 PD-Parkin patients had results of olfactory assessment. PD -Parkin patients performed significantly better on the Sniffin' Sticks tests than panel negative patients (8.0 ± 1.7 vs. 5.7 ± 1.9, p < .001), but still worse compared to healthy controls (9.4 ± 1.5, p = .003)....Continue Reading

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Citations

Nov 21, 2019·Journal of Alzheimer's Disease : JAD·Mahraz Parvand, Catharine H Rankin
Jun 18, 2020·Frontiers in Neurology·Bruce A Chase, Katerina Markopoulou
Jul 6, 2019·Parkinsonism & Related Disorders·Nicki Niemann, Joseph Jankovic

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Methods Mentioned

BETA
Illumina sequencing
ubiquitination

Key Resources (RRID) Mentioned

SCR_001888
SCR_006169
SCR_002865

Software Mentioned

SPSS

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