Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation

Nature Communications
M Cameron OggMax L Fletcher

Abstract

Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. We characterize these processes in the mouse olfactory bulb (OB) and uncover a role for OB acetylcholine (ACh) in physiological and behavioral olfactory dishabituation. We use calcium imaging in both awake and anesthetized mice to determine the time course and magnitude of OB glomerular habituation during a prolonged odor presentation. In addition, we develop a novel behavioral investigation paradigm to determine how prolonged odor input affects odor salience. We find that manipulating OB ACh release during prolonged odor presentations using electrical or optogenetic stimulation rapidly modulates habituated glomerular odor responses and odor salience, causing mice to suddenly investigate a previously ignored odor. To demonstrate the ethological validity of this effect, we show that changing the visual context can lead to dishabituation of odor investigation behavior, which is blocked by cholinergic antagonists in the OB.

References

May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S L FooteF E Bloom
Jun 1, 1995·The European Journal of Neuroscience·A VankovS J Sara
May 2, 1998·Journal of Neurophysiology·D A Wilson
Aug 15, 1998·Journal of Neurophysiology·D A Wilson
Jan 4, 2001·The Journal of Physiology·J Reisert, H R Matthews
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
May 29, 2003·Biophysical Journal·Rodolfo MadridJuan Bacigalupo
Jan 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron R Best, Donald A Wilson
Jan 30, 2004·Learning & Memory·Donald A WilsonRegina M Sullivan
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron R BestDonald A Wilson
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·James R SchaferFuqiang Xu
Apr 15, 2006·The Journal of Comparative Neurology·Rodrigo A España, Craig W Berridge
Dec 13, 2006·The European Journal of Neuroscience·Nathalie MandaironChristiane Linster
Jan 23, 2008·Chemical Senses·Angela Pignatelli, Ottorino Belluzzi
Sep 12, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yusuke TsunoKensaku Mori
Oct 16, 2008·Neurobiology of Learning and Memory·Catharine H RankinRichard F Thompson
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen D SheaRichard Mooney
Jan 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dipesh ChaudhuryChristiane Linster
Apr 4, 2009·Neural Plasticity·Jonathan J SmithDonald A Wilson
Apr 21, 2009·Nature Reviews. Neuroscience·Martin SarterW Matthew Howe
Aug 11, 2010·Behavioral Neuroscience·Dipesh ChaudhuryChristiane Linster
Oct 29, 2010·Learning & Memory·Max L Fletcher, Wei R Chen
Jul 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sudeshna DasMani Ramaswami
Dec 7, 2011·Frontiers in Integrative Neuroscience·Selmaan N ChettihJavier F Medina
Jul 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming Ma, Minmin Luo
Oct 29, 2013·Nature Neuroscience·Lucas PintoYang Dan
Mar 4, 2014·Nature Neuroscience·Brittany N CazakoffStephen D Shea
Mar 29, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Markus RothermelMatt Wachowiak
Nov 8, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shane A HeineyJavier F Medina
Apr 10, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaolin LiuMichael T Shipley
Nov 13, 2015·Journal of Neurophysiology·Sasha DevoreChristiane Linster
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Howard J GrittonMartin Sarter

❮ Previous
Next ❯

Citations

Jun 13, 2019·Acta Physiologica·Anan LiDiego Restrepo
Jan 3, 2019·The Journal of Physiological Sciences : JPS·Sae UchidaFusako Kagitani
May 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yang ShenSaket Navlakha
Apr 17, 2020·Frontiers in Neural Circuits·Jordan M Ross, Jordan P Hamm
Aug 6, 2019·Frontiers in Behavioral Neuroscience·Jordan M RossMax L Fletcher
Jul 3, 2020·Scientific Reports·Erik BöhmMarkus Rothermel
Feb 20, 2021·Frontiers in Cellular Neuroscience·Elizabeth HansonBenjamin R Arenkiel
Aug 21, 2021·Frontiers in Cellular Neuroscience·Carlotta Martelli, Douglas Anthony Storace

❮ Previous
Next ❯

Software Mentioned

Prism
NoRMCorre
R
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.