Olfactory bulb axonal outgrowth is inhibited by draxin

Biochemical and Biophysical Research Communications
Giasuddin AhmedHideaki Tanaka

Abstract

Olfactory bulb (OB) projection neurons receive sensory input from olfactory receptor neurons and precisely relay it through their axons to the olfactory cortex. Thus, olfactory bulb axonal tracts play an important role in relaying information to the higher order of olfactory structures in the brain. Several classes of axon guidance molecules influence the pathfinding of the olfactory bulb axons. Draxin, a recently identified novel class of repulsive axon guidance protein, is essential for the formation of forebrain commissures and can mediate repulsion of diverse classes of neurons from chickens and mice. In this study, we have investigated the draxin expression pattern in the mouse telencephalon and its guidance functions for OB axonal projection to the telencephalon. We have found that draxin is expressed in the neocortex and septum at E13 and E17.5 when OB projection neurons form the lateral olfactory tract (LOT) rostrocaudally along the ventrolateral side of the telencephalon. Draxin inhibits axonal outgrowth from olfactory bulb explants in vitro and draxin-binding activity in the LOT axons in vivo is detected. The LOT develops normally in draxin-/- mice despite subtle defasciculation in the tract of these mutants. These re...Continue Reading

References

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Jan 20, 2009·Science·Shahidul M IslamHideaki Tanaka
Oct 8, 2009·Neuroscience Research·Sanbing ZhangHideaki Tanaka

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Citations

May 17, 2014·Biochemical and Biophysical Research Communications·M Asrafuzzaman RiyadhHideaki Tanaka
Sep 22, 2016·In Vitro Cellular & Developmental Biology. Animal·Sanbing ZhangHideaki Tanaka
May 21, 2016·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Sanbing ZhangYuhong Su
Apr 11, 2018·Biochemical and Biophysical Research Communications·Hiroshi TawarayamaShuntaro Ikawa

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