Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance.

Neural Development
Thomas K KnottGerald A Schwarting

Abstract

The defining feature of the main olfactory system in mice is that each olfactory sensory neuron expresses only one of more than a thousand different odorant receptor genes. Axons expressing the same odorant receptor converge onto a small number of targets in the olfactory bulb such that each glomerulus is made up of axon terminals expressing just one odorant receptor. It is thought that this precision in axon targeting is required to maintain highly refined odor discrimination. We previously showed that β3GnT2(-/-) mice have severe developmental and axon guidance defects. The phenotype of these mice is similar to adenylyl cyclase 3 (AC3) knockout mice largely due to the significant down-regulation of AC3 activity in β3GnT2(-/-) neurons. Microarray analysis reveals that nearly one quarter of all odorant receptor genes are down regulated in β3GnT2(-/-) mice compared to controls. Analysis of OR expression by quantitative PCR and in situ hybridization demonstrates that the number of neurons expressing some odorant receptors, such as mOR256-17, is increased by nearly 60% whereas for others such as mOR28 the number of neurons is decreased by more than 75% in β3GnT2(-/-) olfactory epithelia. Analysis of axon trajectories confirms that...Continue Reading

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Citations

Sep 26, 2012·Molecular and Cellular Neurosciences·Timothy R HenionGerald A Schwarting
Mar 19, 2014·The European Journal of Neuroscience·Xavier Nicol, Patricia Gaspar
Aug 2, 2013·Human Molecular Genetics·Alan R SandersPablo V Gejman
Sep 27, 2020·Protein Science : a Publication of the Protein Society·Lucas C WheelerMichael J Harms
Dec 15, 2017·Biochemistry·Lucas C WheelerMichael J Harms

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Methods Mentioned

BETA
gene array
PCR
gene
glycosylation
chips
chip

Software Mentioned

Primer3
SigmaStat
Expression Console

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