PMID: 9547468Apr 21, 1998Paper

Olfactory dysfunction discriminates Alzheimer's dementia from major depression

The Journal of Neuropsychiatry and Clinical Neurosciences
G S SolomonH B Brackin

Abstract

This study tested the hypothesis that olfactory dysfunction could discriminate between groups of patients with Alzheimer's disease and major depression. Forty patients meeting DSM-IV criteria for Alzheimer's disease and for major depression (20 per group) underwent assessment with the Pocket Smell Test (PST), a three-item screening measure of cranial nerve I function. A PST score of < or = 1 (1 or 0 correct) discriminated between the groups with a hit rate of 90% (sensitivity = 80%, specificity = 100%). Olfactory assessment may be a useful adjunctive screening measure in differentiating Alzheimer's disease from depression in elderly patients.

Citations

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