Abstract
Several neurodegenerative disorders show olfactory dysfunction. In patients with frontotemporal dementia (FTD), olfactory impairment is probably due to the involvement of the temporal and orbitofrontal lobes. We hypothesized that due to the disrupted areas in FTD, there would be an impairment in smell identification, differentiation and association. Moreover, we hypothesized that there would be a correlation between the severity of FTD and the severity of odor dysfunction. In the current study, we compared odor identification, discrimination and association of nine patients with behavioral variant FTD with eleven healthy controls using the Brief Smell Identification Test and the Odor Perception and Semantics Battery. The results showed significant differences in the odor association test, but not in the identification or discrimination test. There was no correlation between disease severity and the performance in the odor tests. We showed impairment of odor association that is most likely due to disruption of specific associative areas involved in olfactory processing. Specifically, we propose that the impairment may well be due to disrupted areas in the temporal lobe and amygdala.
References
Jan 1, 1975·Confinia Neurologica·O J AndyJ R Hughes
Jan 1, 1983·Neuropsychologia·B EskenaziK B Friend
Jun 1, 1983·Brain : a Journal of Neurology·H EichenbaumS Corkin
Apr 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry
Dec 17, 1998·Neurology·D NearyD F Benson
Feb 9, 1999·Journal of Cognitive Neuroscience·J P RoyetJ C Froment
Apr 1, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·D H Zald, J V Pardo
Jul 15, 2000·Neuron·I SavicP Roland
Dec 13, 2000·Neurology·B DuboisB Pillon
Nov 13, 2002·JAMA : the Journal of the American Medical Association·Claire MurphyDavid M Nondahl
Nov 8, 2006·Human Brain Mapping·Jane PlaillyDavid A Kareken
Feb 3, 2007·Neuropsychologia·Simona LuzziMatthew A Lambon Ralph
Sep 19, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Nicole C R McLaughlin, Holly James Westervelt
Jan 8, 2008·Dementia and Geriatric Cognitive Disorders·Yolande A L PijnenburgCees Jonker
Jan 14, 2009·Archives of Neurology·Matteo PardiniJordan Grafman
May 19, 2010·Neurology·E MioshiJ R Hodges
Nov 10, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Rohani OmarJason D Warren
Nov 26, 2013·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Riddhi M Patel, Jayant M Pinto
Feb 27, 2014·Frontiers in Psychology·Richard L Doty, Vidyulata Kamath
May 15, 2015·Gerontology·Johannes AttemsKurt A Jellinger
Citations
Aug 2, 2016·Journal of Anatomy·Ross FergusonVasanta Subramanian
Oct 21, 2017·Brain : a Journal of Neurology·David C PerryHoward J Rosen
Nov 5, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Davangere P DevanandRichard Mayeux
May 12, 2019·Alzheimer's Research & Therapy·Maryam Yahiaoui-DoktorChristoph Engel
May 11, 2018·American Journal of Alzheimer's Disease and Other Dementias·Alessandro Tonacci, Lucia Billeci
Aug 22, 2018·Annals of Clinical and Translational Neurology·Cristina VigueraNicholas J Maragakis
Apr 3, 2020·Neurology·Tatiana Bremova-ErtlSusanne A Schneider
Jul 10, 2019·Dementia & Neuropsychologia·Maren de Moraes E SilvaMaria Carolina Zavagna Witt
Aug 21, 2020·Neuroscience and Biobehavioral Reviews·Sarah Ellen CarnemollaAurélie L Manuel
Jul 3, 2021·International Journal of Environmental Research and Public Health·Naina Bhatia-Dey, Thomas Heinbockel
Aug 24, 2021·Geriatric Nursing·Hyegyeong ChaHan-Song Kim