Olfactory dysfunction persists after smoking cessation and signals increased cardiovascular risk

International Forum of Allergy & Rhinology
Jesse K SiegelJayant M Pinto

Abstract

Olfaction plays a critical role in health and function in older adults, and impaired sense of smell is a strong predictor of morbidity and mortality. Smoking cigarettes causes olfactory impairment, but the mechanism of damage and ability to recover after cessation are unknown. We investigated the relationship between time since quitting and olfactory dysfunction in order to elucidate the mechanism(s) by which smoking damages the olfactory system and to inform patient counseling. Using longitudinal data from the National Social Life Health and Aging Project (n = 3528 older adults, including 1526 former smokers), we analyzed the association between odor identification performance and time since smoking cessation using multivariate ordinal logistic regression, adjusting for cognition and demographic variables. To test whether vascular disease plays a role, we also assessed the relationship between olfactory decline and incidence of heart attack and heart disease. Former smokers who quit ≤15 years before testing had significantly impaired olfaction compared to never smokers (p = 0.04), but those who quit >15 years prior did not. Olfactory decline over 5 years showed modest evidence toward predicting increased incidence of heart att...Continue Reading

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Citations

Nov 15, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eva PalmquistErika J Laukka
Aug 1, 2020·Frontiers in Aging Neuroscience·Kenji KondoTatsuya Yamasoba
Sep 5, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ingrid EkströmErika J Laukka
Oct 23, 2020·JAMA Otolaryngology-- Head & Neck Surgery·Janet S ChoiBozena Wrobel
Jan 12, 2021·The Journal of Sexual Medicine·Jesse K SiegelJayant M Pinto
Sep 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hao LvYu Xu
Jul 30, 2021·Ageing Research Reviews·Xiuli DanVilhelm A Bohr
Oct 22, 2021·Chemical Senses·Emily J Papazian, Jayant M Pinto

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