Olfactory ensheathing cells: characteristics, genetic engineering, and therapeutic potential

Journal of Neurotrauma
Marc J RuitenbergGiles W Plant

Abstract

Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in axonal damage and subsequent loss of communication between neuronal networks, causing long-term functional deficits. For CNS regeneration, repair strategies need to be developed that promote regrowth of lesioned axon projections and restoration of neuronal connectivity. After spinal cord injury (SCI), cystic cavitations are often found, particularly in the later stages, due to the loss of neural tissue at the original impact site. Ultimately, for the promotion of axonal regrowth in these situations, some form of transplantation will be required to provide lesioned axons with a supportive substrate along which they can extend. Here, we review the use of olfactory ensheathing cells: their location and role in the olfactory system, their use as cellular transplants in SCI paradigms, alone or in combination with gene therapy, and the unique properties of these cells that may give them a potential advantage over other cellular transplants.

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Citations

Jul 25, 2012·Cell Biochemistry and Biophysics·Manuel Pérez-GarnésManuel Monleón Pradas
Feb 7, 2009·Journal of Neurotrauma·Michael D KawajaRon Doucette
Nov 8, 2008·Molekuliarnaia biologiia·E N Kozlova
May 29, 2014·Plastic and Reconstructive Surgery·Amit PabariAsh Mosahebi
Aug 21, 2014·International Journal of Molecular Sciences·Yuxi HeGuanfang Su
Sep 30, 2009·Journal of Neuroscience Methods·Chiara AudisioIsabelle Perroteau
Sep 4, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N SrivastavaA K Agrawal
Nov 22, 2007·Advanced Drug Delivery Reviews·Stephanie M Willerth, Shelly E Sakiyama-Elbert
Mar 9, 2018·MRS Communications·Radamés Ayala-CamineroJorge Almodovar
May 1, 2009·Personalized Medicine·Alexandros A Lavdas, Rebecca Matsas

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