Olfactory function in patients with multiple sclerosis: a diffusion tensor imaging study

Journal of the Neurological Sciences
Katharina ErbLutz Lüdemann

Abstract

Previous research has shown that multiple sclerosis (MS) patients can develop olfactory disturbances. The purpose of our study was to investigate how olfactory function in MS patients correlates with cerebral magnetic resonance imaging (MRI) including diffusion tensor imaging (DTI). Olfactory performance was tested in 30 MS patients and 30 controls to determine odour threshold (T), odour discrimination (D), and odour identification (I) summarised in the TDI score. The lesion load (number and total volume of lesions) was measured on proton-density (PD)- and T2-weighted images of the olfactory brain and the total brain. Fractional anisotropy (FA) of the lesions and the surrounding normal-appearing brain tissue (NABT) was quantified using DTI. The median FA of white matter lesions was 0.29 and was on average 11.1% lower than in the surrounding NABT. The normalised TDI score and the normalised I subscore were significantly poorer in the MS group compared to controls (p<0.0001), while the T and D subscores were similar in both groups. The median FA of lesions in the olfactory brain correlated inversely with the decreased I subscore (p=0.001). There was also a strong correlation between the TDI score and the Expanded Disability Statu...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1987·Biological Psychiatry·J D AmsterdamA Winokur
Aug 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C S ConstantinescuR L Doty
Feb 4, 1999·Annals of the New York Academy of Sciences·R L DotyD M Yousem
Jun 27, 2000·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G KobalT Hummel
Feb 24, 2001·Multiple Sclerosis : Clinical and Laboratory Research·M ZorzonR Zivadinov
Jun 5, 2002·Current Opinion in Neurology·Frederik Barkhof
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Dec 10, 2003·Archives of General Psychiatry·Bruce I TuretskyRaquel E Gur
Feb 10, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Robert Zivadinov, Rohit Bakshi
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Nov 26, 2008·NeuroImage·S D RoosendaalF Barkhof
Dec 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elise WattendorfBirgit Westermann
Mar 5, 2011·Multiple Sclerosis : Clinical and Laboratory Research·A LutterottiT Berger
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Apr 14, 2011·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·F A SchmidtO Göktas
May 19, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Stefan D RoosendaalJeroen J G Geurts
May 26, 2011·PloS One·Felix Alexander SchmidtFranca Fleiner

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Citations

Apr 12, 2016·Multiple Sclerosis and Related Disorders·Elisabeth B LucassenPaul Eslinger
Sep 14, 2014·Journal of the Neurological Sciences·Katharina Erb-EignerLutz Lüdemann
Sep 18, 2014·Brain Pathology·Gabriele C DeLucaMargaret M Esiri
Oct 7, 2015·Frontiers in Neuroscience·Lorenza RattazziFulvio D'Acquisto
May 31, 2014·BioMed Research International·Yujuan ShenLi Zhou
Nov 5, 2016·Physiology & Behavior·Kimberley P GoodRichard L Doty
Mar 24, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Albert Joseph, Gabriele C DeLuca
Dec 1, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Gabriel BstehAndreas Lutterotti
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·Juliette HeinrichEmmanuelle Duron
Sep 19, 2019·Brain Topography·Pengfei HanThomas Hummel
Nov 23, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Gabriel BstehThomas Berger
Apr 21, 2017·Journal of Child Neurology·Harvey B SarnatXing-Chang Wei
Sep 8, 2018·Molecular Neurobiology·Taekyun ShinChangjong Moon

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