Olfactory glia enhance neonatal axon regeneration

Molecular and Cellular Neurosciences
Fatemeh ChehrehasaJames A St John

Abstract

Olfactory ensheathing cells (OECs) migrate with olfactory axons that extend from the nasal epithelium into the olfactory bulb. Unlike other glia, OECs are thought to migrate ahead of growing axons instead of following defined axonal paths. However it remains unknown how the presence of axons and OECs influences the growth and migration of each other during regeneration. We have developed a regeneration model in neonatal mice to examine whether (i) the presence of OECs ahead of olfactory axons affects axonal growth and (ii) the presence of olfactory axons alters the distribution of OECs. We performed unilateral bulbectomy to ablate olfactory axons followed by methimazole administration to further delay neuronal growth. In this model OECs filled the cavity left by the bulbectomy before new axons extended into the cavity. We found that delaying axon growth increased the rate at which OECs filled the cavity. The axons subsequently grew over a significantly larger region and formed more distinct fascicles and glomeruli in comparison with growth in animals that had undergone only bulbectomy. In vitro, we confirmed (i) that olfactory axon growth was more rapid when OECs were more widely distributed than the axons and (ii) that OECs mi...Continue Reading

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Citations

Apr 27, 2012·Journal of Materials Science. Materials in Medicine·Jorge Luis Escobar IviricoManuel Monleón Pradas
Jul 25, 2012·Cell Biochemistry and Biophysics·Manuel Pérez-GarnésManuel Monleón Pradas
Feb 15, 2011·Cellular and Molecular Life Sciences : CMLS·Louisa C E WindusJames A St John
Oct 30, 2013·Journal of Anatomy·Maurizio LazzariValeria Franceschini
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jenny A K Ekberg, James A St John
Aug 15, 2014·The Journal of Comparative Neurology·Daniel A AmayaJames A St John
Jun 28, 2011·Molecular and Cellular Neurosciences·Katie E LineburgJames A St John
Jun 28, 2016·Molecular and Cellular Neurosciences·Johana Tello VelasquezJames A St John
May 13, 2014·Cell Transplantation·Ruey-Hwang ChouWoei-Cherng Shyu
Apr 12, 2018·Cell Transplantation·Hongyun HuangTong Li
Mar 30, 2012·Neuro-Signals·Jenny A K EkbergJames A St John
Oct 15, 2011·Biotechnology and Applied Biochemistry·Tina SedaghatiAlexander M Seifalian
Aug 24, 2018·Neural Regeneration Research·Kate BeecherFatemeh Chehrehasa
Dec 29, 2018·The Journal of Comparative Neurology·Lynn NazarethJenny A K Ekberg
Feb 27, 2020·Nature Reviews. Neurology·Susan L LindsaySusan C Barnett
May 11, 2017·Journal of Cellular and Molecular Medicine·Nunzio VicarioRosalba Parenti
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Mar 21, 2018·Neural Regeneration Research·Jian WengBao-Guo Jiang
Mar 14, 2018·Molecular Neurobiology·Godwin SokporTran Tuoc
Jul 22, 2018·Neural Regeneration Research·Kate BeecherFatemeh Chehrehasa
Oct 15, 2019·Frontiers in Molecular Neuroscience·Marziah HakimFatemeh Chehrehasa
Feb 15, 2020·Journal of Neurotrauma·Aaron D GilmourJames A St John
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Lynn NazarethJenny Ekberg
Jun 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu-Ting TsengJenny Ekberg

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