Olfactory identification testing as a predictor of the development of Alzheimer's dementia: a systematic review

The Laryngoscope
Gordon H SunJames F Burke

Abstract

To evaluate the utility of olfactory identification tests as prognostic instruments for Alzheimer's dementia (AD). Systematic review. In accordance with PRISMA guidelines, PubMed and Ovid MEDLINE, EMBASE, ISI Web of Science, PsycINFO, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched to determine the quality and quantity of longitudinal and cross-sectional research on this topic. Two prospective longitudinal cohort studies and 30 cross-sectional studies met inclusion criteria. The prospective longitudinal studies evaluated subjects with or without mild cognitive impairment (MCI) while also using olfactory identification testing as part of a neurocognitive evaluation. The first study reported an increased risk of later onset of AD in subjects with baseline hyposmia, whereas the second study suggested a possible relationship between decreased olfaction in participants with MCI and conversion to AD but was inconclusive due to low follow-up rates. Wide variability in the type of olfactory identification test used and the reporting of results precluded meta-analysis. The cross-sectional studies demonstrated a positive association between poorer performance on olfactory ...Continue Reading

References

Mar 1, 1991·The American Journal of Psychiatry·M SerbyD Kalkstein
Jan 1, 1986·Biological Psychiatry·M D WarnerJ R Tinklenberg
Mar 1, 1997·Neurobiology of Aging·P J MobergR E Gur
Oct 29, 1997·JAMA : the Journal of the American Medical Association·S S Schiffman
Aug 31, 2000·The American Journal of Psychiatry·D P DevanandR Mayeux
Feb 24, 2001·Neuropsychology·D A KarekenG D Hutchins
May 23, 2001·Chemical Senses·J P RoyetJ Guerin
May 7, 2002·Journal of Clinical and Experimental Neuropsychology·Agnes ChanLinda Lam
Sep 21, 2002·Journal of the International Neuropsychological Society : JINS·Charlie D Morgan, Claire Murphy
Apr 2, 2003·Journal of the International Neuropsychological Society : JINS·Claire MurphyChristine Fennema-Notestine
Aug 4, 2004·International Journal of Geriatric Psychiatry·Y SuzukiA Iguchi
Apr 27, 2005·Journal of Alzheimer's Disease : JAD·Johannes AttemsKurt A Jellinger
Jun 29, 2005·Annals of Neurology·Matthias H TabertD P Devanand
Dec 22, 2005·The Laryngoscope·Alexis H Jackman, Richard L Doty
Jan 24, 2006·International Archives of Occupational and Environmental Health·Richard L Doty
Jan 9, 2007·Neurobiology of Aging·Jelena DjordjevicHoward Chertkow
Feb 15, 2007·International Journal of Geriatric Psychiatry·Grete KjelvikLinda R White
May 16, 2007·Neurology·C C RoweV L Villemagne
Jul 4, 2007·Aging Clinical and Experimental Research·Michael PentzekRalf Ihl
Sep 19, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Nicole C R McLaughlin, Holly James Westervelt
Sep 22, 2007·American Journal of Rhinology·Richard L Doty
Aug 30, 2008·Biological Psychiatry·Davangere P DevanandGregory H Pelton
Oct 22, 2008·Journal of Clinical and Experimental Neuropsychology·Holly James WesterveltGeoffrey Tremont
Jan 13, 2009·Otolaryngologic Clinics of North America·Denis Lafreniere, Norman Mann
Mar 31, 2009·International Psychogeriatrics·S JungwirthP Fischer
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Sep 4, 2009·Journal of Neurology·Silke SteinbachThomas Zahnert
Mar 17, 2010·Archives of Otolaryngology--head & Neck Surgery·Simona NegoiasThomas Hummel
Apr 28, 2010·Expert Review of Neurotherapeutics·Daniel W WessonRalph A Nixon
May 4, 2010·Annals of Neurology·Steven E ArnoldJohn Q Trojanowski
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Paul S AisenUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 12, 2010·Neurobiology of Aging·A CaroliUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Citations

Apr 20, 2013·International Psychogeriatrics·Latha VelayudhanSimon Lovestone
May 15, 2013·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Marta Zaffira ContiLuca Rozzini
Feb 21, 2014·Acta Neuropathologica·Johannes AttemsKurt A Jellinger
Jul 24, 2014·Current Neurology and Neuroscience Reports·Peter W SchofieldYun Ming Yong
Mar 15, 2014·Brazilian Journal of Otorhinolaryngology·Luciano Lobato GregorioEduardo Kosugi Macoto
Aug 12, 2014·HNO·S EichhornA Laubert
Nov 2, 2014·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·David W KernMartha K McClintock
May 25, 2015·Aging Clinical and Experimental Research·Giancarlo OttavianoAlessandro Martini
Feb 12, 2014·Journal of the American Medical Directors Association·Heather KellerCatriona Steele
Aug 10, 2013·Journal of the Neurological Sciences·Jennifer J StampsKenneth M Heilman
Jan 17, 2015·Current Opinion in Psychiatry·Latha Velayudhan
May 24, 2014·The Australian and New Zealand Journal of Psychiatry·Henry BrodatyUNKNOWN PRIME study group
Apr 21, 2017·The Journal of Laryngology and Otology·A GrosR David
Jan 1, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·David R RoalfPaul J Moberg
Dec 22, 2017·The Laryngoscope·Andreas Steenholt NiklassenAlexander Wieck Fjaeldstad
Mar 13, 2015·British Journal of Hospital Medicine·Irfan Syed, Carl Philpott
Jun 16, 2018·Current Allergy and Asthma Reports·Concepció MarinJoaquim Mullol
Jan 17, 2020·Applied Neuropsychology. Adult·Azadeh Sadat ZendehbadMohsen Davoudkhani
Nov 5, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Davangere P DevanandRichard Mayeux
Jul 1, 2017·Neurology·Marie-Elyse Lafaille-MagnanUNKNOWN PREVENT-AD Research Group
Nov 19, 2014·World Journal of Clinical Cases·Jorge AlvesRosana Magalhães
May 22, 2019·Chemical Senses·Davangere P DevanandSeonjoo Lee
Apr 3, 2019·Annual Review of Public Health·Kimberly C PaulBeate R Ritz
Jul 8, 2017·Scientific Reports·Yumi Umeda-KameyamaMasahiro Akishita
Sep 26, 2017·Journal of the American Geriatrics Society·Dara R AdamsJayant M Pinto
Oct 6, 2017·Chemical Senses·Daphnée PouponJohannes Frasnelli
Apr 25, 2020·International Journal of Molecular Sciences·Naina Bhatia-Dey, Thomas Heinbockel
Aug 21, 2020·Neuroscience and Biobehavioral Reviews·Sarah Ellen CarnemollaAurélie L Manuel
Nov 19, 2020·International Journal of Environmental Research and Public Health·Sun Mi KimDoug Hyun Han
Jun 3, 2018·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Matthew R WoodwardUNKNOWN Texas Alzheimer's Research, Care Consortium
Mar 23, 2021·OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation·Jennifer LiJennifer A Villwock
Jun 8, 2021·Topics in Magnetic Resonance Imaging : TMRI·Israel Saramago, Ana M Franceschi
Jul 13, 2021·I-Perception·Jonas K OlofssonSteven Nordin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.