Olfactory implant: Demand for a future treatment option in patients with olfactory dysfunction

The Laryngoscope
Gerold BesserChristian A Mueller

Abstract

Therapeutic options in olfactory dysfunction (OD) are limited. Numerous studies have shown impact of OD on quality of life. Lately, various studies support benefits of olfactory training, but therapy-refractory cases leave doctors and patients locked in a stalemate. An olfactory implant (OI), in analogy to the widely successful cochlear implant, still seems far away from realization. The present study sought to evaluate the demand of OI in patients with OD. Sixty-one patients (28 females and 33 males, mean age/standard deviation 54.9/17.6 years) with OD were recruited. We performed olfactory testing for threshold (T), discrimination (D), and identification (I) using Sniffin' Sticks; summed scores (TDI) allowed us to determine normosmia, hyposmia, and anosmia. We applied questionnaires on the importance of smell (IOS), on olfactory disorders (QOD) and on the interest/willingness for OI, considering the need for skull base/head surgery. Twenty-one patients (34.4%) stated that OI could be a future treatment option for them. This decision significantly correlated with TDI, I, complaint-related questions of the QOD, and IOS (P < .05). With approximately one-third of patients considering OI as a therapy option, this study seems to in...Continue Reading

References

Jun 27, 2000·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G KobalT Hummel
May 18, 2001·Archives of Otolaryngology--head & Neck Surgery·T MiwaE R Reiter
Jun 7, 2002·Archives of Otolaryngology--head & Neck Surgery·Andreas F P TemmelThomas Hummel
Nov 25, 2003·Chemical Senses·B N LandisJ S Lacroix
Apr 6, 2004·The Laryngoscope·Annika BrämersonMats Bende
May 11, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Johannes Frasnelli, Thomas Hummel
Oct 6, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T HummelA Mackay-Sim
Aug 5, 2008·Journal of Neurology·Mechtild M VennemannKlaus Berger
Jul 25, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ilona CroyThomas Hummel
Nov 26, 2009·Rhinology·Basile N LandisThomas Hummel
Jul 24, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Therese Fark, Thomas Hummel
May 21, 2013·The Laryngoscope·Michael KatotomichelakisVassilios Danielides
Jan 17, 2014·Chemical Senses·Ilona CroyThomas Hummel
Jul 10, 2016·Journal of Neurology·Ilona Croy, Thomas Hummel
Jan 4, 2017·Rhinology·A SorokowskaT Hummel
Mar 13, 2018·Rhinology. Supplement·T HummelA Welge-Luessen
May 8, 2018·Brain Sciences·Marion RochetBoriana Atanasova
Jun 11, 2018·Journal of Affective Disorders·Luise D PabelIlona Croy

❮ Previous
Next ❯

Citations

Nov 28, 2018·International Forum of Allergy & Rhinology·Eric H HolbrookDinesh G Nair
Sep 1, 2019·The Laryngoscope·David Tianxiang LiuChristian Albert Mueller
Oct 14, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·David T LiuChristian A Mueller
Nov 7, 2019·Otolaryngologic Clinics of North America·Eric H Holbrook, Daniel H Coelho
Feb 28, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M PingerM Bensafi

❮ Previous
Next ❯

Methods Mentioned

BETA
cochlea implant

Software Mentioned

R Foundation for
QOD
GraphPrism
SPSS
R Statistical Computing
NS
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
Aylin Gülİsmail Topçu
© 2022 Meta ULC. All rights reserved