Respiration and airflow through the nasal cavity are known to be correlated with rhythmic neural activity in the central nervous system. Here we show in rodents that during conditioned fear-induced freezing behavior, mice breathe at a steady rate (~4 Hz), which is correlated with a predominant 4-Hz oscillation in the prelimbic prefrontal cortex (plPFC), a structure critical for expression of conditioned fear behaviors. We demonstrate anatomical and functional connections between the olfactory pathway and plPFC via circuit tracing and optogenetics. Disruption of olfactory inputs significantly reduces the 4-Hz oscillation in the plPFC, but leads to prolonged freezing periods. Our results indicate that olfactory inputs can modulate rhythmic activity in plPFC and freezing behavior.
The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans
Voluntary hyperventilation in the treatment of panic disorder--functions of hyperventilation, their implications for breathing training, and recommendations for standardization
Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia
Comparative analysis of the frequency and distribution of stem and progenitor cells in the adult mouse brain
Age-related changes of the regeneration mode in the mouse peripheral olfactory system following olfactotoxic drug methimazole-induced damage
Respiration drives network activity and modulates synaptic and circuit processing of lateral inhibition in the olfactory bulb
Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex
Ventromedial prefrontal cortex reactivity is altered in generalized anxiety disorder during fear generalization
Olfactory consciousness and gamma oscillation couplings across the olfactory bulb, olfactory cortex, and orbitofrontal cortex
G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons
Minimally invasive highly precise monitoring of respiratory rhythm in the mouse using an epithelial temperature probe
Local cortical activity of distant brain areas can phase-lock to the olfactory bulb's respiratory rhythm in the freely behaving rat
Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis
Plasticity of Sniffing Pattern and Neural Activity in the Olfactory Bulb of Behaving Mice During Odor Sampling, Anticipation, and Reward
Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction.
Respiration and brain neural dynamics associated with interval timing during odor fear learning in rats
Behavioral and EEGraphic Characterization of the Anticonvulsant Effects of the Predator Odor (TMT) in the Amygdala Rapid Kindling, a Model of Temporal Lobe Epilepsy
Nasal respiration is necessary for ketamine-dependent high frequency network oscillations and behavioral hyperactivity in rats.
Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models.
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.
Amygdala: Sensory Processes
Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.