Olfactory memory in the old and very old: relations to episodic and semantic memory and APOE genotype

Neurobiology of Aging
Maria LarssonErika Jonsson Laukka

Abstract

The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to investigate whether olfactory memory in old age is best conceptualized as a distinct category, differentiated from episodic and semantic memory. Further, potential olfactory dedifferentiation and genetic associations (APOE) to olfactory function in late senescence were investigated. Results are in support of a 3-factor solution where olfactory memory, as indexed by episodic odor recognition and odor identification, is modeled separately from episodic and semantic memory for visual and verbal information. Increasing age was associated with poorer olfactory memory performance, and observed age-related deficits were further exacerbated for carriers of the APOE ε4 allele; these effects tended to be larger for olfactory memory compared to episodic and semantic memory pertaining to other sensory systems (vision, auditory). Finally, stronger correlations between olfactory and episodic memory, indicating dedifferentiation...Continue Reading

References

Jan 1, 1985·Memory & Cognition·M Glanzer, J K Adams
Dec 21, 1984·Science·R L DotyL Rosenberg
Mar 1, 1995·Physiology & Behavior·N L SegalL Araki
Feb 4, 1999·Annals of the New York Academy of Sciences·N E RawsonD Restrepo
Feb 4, 1999·Annals of the New York Academy of Sciences·C MurphyD P Salmon
Jul 10, 1999·Neuroscience Letters·R G StrubleB P Nathan
Aug 31, 2000·The American Journal of Psychiatry·D P DevanandR Mayeux
Jul 11, 2001·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·D FinkelM Larsson
Aug 8, 2002·Journal of the International Neuropsychological Society : JINS·Christina ObergLars Bäckman
Nov 13, 2002·JAMA : the Journal of the American Medical Association·Claire MurphyDavid M Nondahl
Jan 14, 2004·Journal of Personality and Social Psychology·Ian J DearyHelen C Fox
Jun 29, 2005·Annals of Neurology·Matthias H TabertD P Devanand
Oct 3, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·R S WilsonD A Bennett
Oct 6, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T HummelA Mackay-Sim
Jan 24, 2007·Brain Research·Britto P NathanRobert G Struble
Dec 8, 2007·Memory & Cognition·Johan Willander, Maria Larsson
Jul 16, 2008·Neurobiology of Aging·Jonas K OlofssonMaria Larsson
Mar 17, 2009·Neurobiology of Aging·Nick M WisdomKeith A Hawkins
Mar 18, 2009·Psychology and Aging·Ulman Lindenberger, Paolo Ghisletta
Aug 19, 2009·Annals of the New York Academy of Sciences·Maria Larsson, Johan Willander
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel W WessonDonald A Wilson
Aug 12, 2010·Nature Reviews. Neuroscience·Jay A Gottfried
Apr 27, 2011·Psychology and Aging·Deborah FinkelNancy L Pedersen
Jun 7, 2011·Psychology and Aging·Richard L DotyKaare Christensen
Jul 27, 2012·Translational Psychiatry·H R SohrabiR N Martins
Sep 27, 2012·Journal of the Neurological Sciences·Marina BarresiSilvia Marino
Jan 2, 2013·Psychology and Aging·Erika J LaukkaLars Bäckman
May 15, 2013·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Marta Zaffira ContiLuca Rozzini
Jul 13, 2013·Journal of Biomedical Science·Aseem HussainBritto P Nathan
Sep 1, 1996·Psychonomic Bulletin & Review·R S Herz, T Engen
Dec 24, 2013·Trends in Neurosciences·Arie S MobleyCharles A Greer
Sep 1, 2005·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Maria LarssonLars Bäckman
Jan 24, 2014·Journal of the International Neuropsychological Society : JINS·Ingrid StanciuJonas K Olofsson
Feb 20, 2014·Frontiers in Psychology·Artin Arshamian, Maria Larsson
Feb 27, 2014·Frontiers in Psychology·Richard L Doty, Vidyulata Kamath
Jul 9, 2014·Neuroscience and Biobehavioral Reviews·Naudin Marine, Atanasova Boriana
Jul 30, 2014·Frontiers in Behavioral Neuroscience·Anne-Lise SaiveJane Plailly

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Citations

Jan 7, 2017·Perception·Rebecka N AddoMaria Larsson
Oct 7, 2017·Journal of Alzheimer's Disease : JAD·Babette L R ReijsPieter Jelle Visser
Jun 18, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Burak YulugErtugrul Kilic
Mar 24, 2017·Chemical Senses·Sara SjölundErika J Laukka
Apr 27, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Janina SeubertMaria Larsson
Dec 14, 2018·Chemical Senses·Ingrid EkströmJonas K Olofsson
Sep 5, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ingrid EkströmErika J Laukka
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Benoît JobinBenjamin Boller
Feb 21, 2021·Pflügers Archiv : European journal of physiology·Wen-Yu TzengOlga Garaschuk
Jul 13, 2021·I-Perception·Jonas K OlofssonSteven Nordin
Oct 16, 2020·ACS Chemical Neuroscience·Grazyna LietzauCesare Patrone

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