Olfactory memory representations are stored in the anterior olfactory nucleus.

Nature Communications
A. J. Aqrabawi, Jun Chul Kim

Abstract

The anterior olfactory nucleus (AON) is the initial recipient of odour information from the olfactory bulb, and the target of dense innervation conveying spatiotemporal cues from the hippocampus. We hypothesized that the AON detects the coincidence of these inputs, generating patterns of activity reflective of episodic odour engrams. Using activity-dependent tagging combined with neural manipulation techniques, we reveal that contextually-relevant odour engrams are stored within the AON and that their activity is necessary and sufficient for the behavioural expression of odour memory. Our findings offer a new model for studying the mechanisms underlying memory representations.

References

Feb 4, 1999·Annals of the New York Academy of Sciences·H Eichenbaum
Oct 19, 2005·Brain Research. Brain Research Reviews·Peter C BrunjesElizabeth A Meyer
Nov 5, 2005·Neuron·Barry W Ache, Janet M Young
Aug 19, 2007·Journal of Neurophysiology·Claire MartinLeslie M Kay
Sep 1, 2007·Science·Leon G ReijmersMark Mayford
Feb 3, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marta I GarridoKarl J Friston
Mar 17, 2009·Science·Jin-Hee HanSheena A Josselyn
Aug 7, 2010·Science·Tiziana Sacco, Benedetto Sacchetti
Aug 11, 2010·Behavioral Neuroscience·Dipesh ChaudhuryChristiane Linster
Sep 20, 2011·Cell·Gloria B ChoiRichard Axel
Dec 19, 2012·Current Biology : CB·Kaycie K TaylerBrian J Wiltgen
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hong XieJi-Song Guan
Jun 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Moriel ZelikowskyMichael S Fanselow
Oct 14, 2014·Neuron·Kiriana K CowansageMark Mayford
Oct 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hwa-Lin Liz HsiangSheena A Josselyn
Aug 21, 2015·Nature Reviews. Neuroscience·Sheena A JosselynPaul W Frankland
Sep 4, 2015·Neuron·Susumu TonegawaRoger Redondo
Feb 24, 2016·Nature Neuroscience·Stéphanie TroucheDavid Dupret
Mar 6, 2016·Learning & Behavior·Howard Eichenbaum
Apr 8, 2017·Science·Takashi KitamuraSusumu Tonegawa
Mar 10, 2018·Frontiers in Neuroanatomy·Afif J Aqrabawi, Jun Chul Kim
Dec 16, 2018·Neuron·Michele PignatelliSusumu Tonegawa
Jan 8, 2019·Current Biology : CB·Claire Meissner-BernardAlexander Fleischmann

❮ Previous
Next ❯

Citations

Jun 20, 2020·Chemical Senses·Albert Y HanIvan A Lopez
Oct 20, 2020·Frontiers in Computational Neuroscience·Thomas A Cleland, Ayon Borthakur
Nov 11, 2020·Current Neurology and Neuroscience Reports·Brian Y HwangVidyulata Kamath
Dec 9, 2020·The European Journal of Neuroscience·Jamie A O'Reilly, Bernard A Conway
Jan 31, 2021·Cell and Tissue Research·Renée HartigWolfgang Kelsch
Dec 24, 2020·Cell and Tissue Research·Daniela Brunert, Markus Rothermel
Mar 1, 2021·Progress in Neurobiology·Guangyu ZhouChristina Zelano
Mar 24, 2021·Brain Research Bulletin·Paula LunardiGrace S Pereira
Apr 4, 2021·Biomedicines·Maria Isabella DoneganiSilvia Morbelli
Sep 1, 2021·Seminars in Cell & Developmental Biology·Sue KulasonAkira Sawa

❮ Previous
Next ❯

Software Mentioned

Photoshop
ANY
maze
GraphPad
Adobe
GraphPad Prism

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.