Olfactory modulation by dopamine in the context of aversive learning.

Journal of Neurophysiology
Andrew M DacksAlan J Nighorn

Abstract

The need to detect and process sensory cues varies in different behavioral contexts. Plasticity in sensory coding can be achieved by the context-specific release of neuromodulators in restricted brain areas. The context of aversion triggers the release of dopamine in the insect brain, yet the effects of dopamine on sensory coding are unknown. In this study, we characterize the morphology of dopaminergic neurons that innervate each of the antennal lobes (ALs; the first synaptic neuropils of the olfactory system) of the moth Manduca sexta and demonstrate with electrophysiology that dopamine enhances odor-evoked responses of the majority of AL neurons while reducing the responses of a small minority. Because dopamine release in higher brain areas mediates aversive learning we developed a naturalistic, ecologically inspired aversive learning paradigm in which an innately appetitive host plant floral odor is paired with a mimic of the aversive nectar of herbivorized host plants. This pairing resulted in a decrease in feeding behavior that was blocked when dopamine receptor antagonists were injected directly into the ALs. These results suggest that a transient dopaminergic enhancement of sensory output from the AL contributes to the ...Continue Reading

References

Jan 1, 1979·Annual Review of Neuroscience·I Kupfermann
Nov 1, 1988·Cell and Tissue Research·U HombergJ G Hildebrand
May 1, 1987·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·T A Christensen, J G Hildebrand
Mar 13, 1995·The Journal of Comparative Neurology·J H McLeanG D Paterno
May 1, 1996·Journal of Neurobiology·T A ChristensenJ G Hildebrand
May 1, 1996·Journal of Neurophysiology·G R HoltR J Douglas
Nov 14, 1997·Brain Research. Developmental Brain Research·P E LangdonJ H McLean
Mar 1, 2000·Trends in Biochemical Sciences·C CombetG Deléage
Apr 28, 2000·Science·T ZarsM Heisenberg
Mar 22, 2001·Nature·N J VickersJ G Hildebrand
Dec 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhengmei MaoRonald L Davis
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kevin C DalyJohn G Hildebrand
Jun 30, 2005·Archives of Insect Biochemistry and Physiology·Julie A MustardAlison R Mercer
Nov 12, 2005·Journal of Neurophysiology·Christopher G Perk, Alison R Mercer
Nov 24, 2005·Current Biology : CB·Alex C Keene, Scott Waddell
Dec 16, 2005·The Journal of Experimental Biology·Sanjay P Sane, Nathaniel P Jacobson
Aug 18, 2006·Ecology Letters·Lynn S AdlerAmanda J Lentz
Aug 29, 2006·Insect Biochemistry and Molecular Biology·Andrew M DacksAlan J Nighorn
Feb 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kyle T BeggsAlison R Mercer
Feb 24, 2007·The Plant Journal : for Cell and Molecular Biology·Danny Kessler, Ian T Baldwin
Apr 3, 2007·Trends in Neurosciences·Wolfram Schultz
May 15, 2007·Ecology Letters·Robert J GegearJames D Thomson
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Young-Cho KimKyung-An Han
Jul 21, 2007·Science·Vanina VergozAlison R Mercer
Oct 31, 2007·Insect Biochemistry and Molecular Biology·Maureen J GormanMichael R Kanost
Nov 8, 2007·The European Journal of Neuroscience·Ning Yuan, Daewoo Lee
Dec 11, 2007·Annual Review of Entomology·Peter Kloppenburg, Alison R Mercer
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey A RiffellJohn G Hildebrand
Mar 18, 2008·Biochemical and Biophysical Research Communications·Shixing ZhangAike Guo
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana F SilberingC Giovanni Galizia
Feb 24, 2009·Current Biology : CB·Jeffrey A RiffellJohn G Hildebrand

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Citations

May 11, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Marie R Clifford, Jeffrey A Riffell
Oct 1, 2013·Neurobiology of Learning and Memory·Martín KlappenbachFernando Locatelli
Feb 26, 2016·Frontiers in Neural Circuits·Samual P BradleyAndrew M Dacks
Sep 1, 2015·Frontiers in Physiology·Carolina E Reisenman, Jeffrey A Riffell
May 20, 2014·Journal of Physiology, Paris·F GuidobaldiP G Guerenstein
Aug 29, 2014·Frontiers in Computational Neuroscience·Eli ShlizermanJ Nathan Kutz
May 23, 2014·Frontiers in Systems Neuroscience·Stephanie L Gage, Alan Nighorn
Mar 6, 2015·PLoS Computational Biology·Jaldert O RomboutsPieter R Roelfsema
Jul 30, 2016·Integrative and Comparative Biology·Winnie W Ho, Jeffrey A Riffell
Nov 13, 2015·The Journal of Comparative Neurology·Kristyn M LizbinskiAndrew M Dacks
Sep 19, 2019·Learning & Memory·Paul MarchalMartin Giurfa
Feb 26, 2020·Nature Communications·Aarush Mohit MittalNitin Gupta
Jul 23, 2016·Frontiers in Physiology·Carolina E ReisenmanPablo G Guerenstein
Mar 1, 2018·The Journal of Experimental Biology·Gabriella H Wolff, Jeffrey A Riffell
Jan 30, 2018·Frontiers in Cellular Neuroscience·Kristyn M Lizbinski, Andrew M Dacks
Nov 5, 2016·Annual Review of Entomology·Patricia L Jones, Anurag A Agrawal
Oct 29, 2020·Frontiers in Cellular Neuroscience·Kirill S KorshunovPaul Q Trombley
Jun 23, 2019·Neural Networks : the Official Journal of the International Neural Network Society·Charles B Delahunt, J Nathan Kutz
Sep 22, 2019·Learning & Memory·Paul MarchalMartin Giurfa
Mar 10, 2021·Biological Reviews of the Cambridge Philosophical Society·Jiayue YanJosué Martínez-de la Puente
Feb 6, 2018·Current Biology : CB·Clément VinaugerJeffrey A Riffell

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