journal cover

Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease

Stem Cells

Jun 7, 2008

Wayne MurrellAlan Mackay-Sim

Abstract

Parkinson's disease is a complex disorder characterized by degeneration of dopaminergic neurons in the substantia nigra in the brain. Stem cell transplantation is aimed at replacing dopaminergic neurons because the most successful drug therapies affect these neurons and their synaptic t...read more

Mentioned in this Paper

Abnormal Degeneration
Neurons
Brain
Stem Cell Transplant
Smell Perception
Substantia Nigra Structure
Olfactory Mucosa
Cell Differentiation Process
Cell Lineage
Neuronal
1
72
Paper Details
References
  • References51
  • Citations71
12345...
  • References51
  • Citations71
12345...

Similar Papers Found In These Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Dopamine & Behavior

Dopamine is a neurotransmitter and a hormone commonly associated with the brain's pleasure and reward system. Here is the latest research on its role in affecting and guiding human behaviour.

Neuronal Identity

Neuronal identity is important for defining the end result of stem cell differentiation through neuronal developmentor for regenerative medicine. This could involved transcription factors used to drive induce pluripotent stem cells towards the neuronal lineage. Discover the latest research on Neuronal Identity here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Lineage Commitment

Lineage commitment is the consolidation of a distinct pattern of gene expression in a cell type distiguising it from its progenitor and other cells derived from its progentior cell. Here is the latest research.

Parkinson's Disease

Parkinson's Disease is a progressive neurodegenerative disorder characterized by loss of muscle control, including trembling of the limbs and impaired balance. Here is the latest research.

Stem Cells in Neurodegenerative Diseases

Stem cells have the potential to develop into many different types of cells in the body and may be useful as a therapy for several diseases including neurodegenerative diseases. Discover the latest research on stem cells and neurodegenerative diseases here.

Striatonigral Degeneration

Striatonigral degeneration is a neurological disorder resulting from a disrupted connection between the striatum and substantia nigra, which enable balance and movement. Here is the latest research.

PVN Neurons from iPSCs

Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors. This feed focuses on the generation of neurons of the paraventricular nucleus of the hypothalamus from iPSCs.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Dopaminergic System

This feed focuses on projection neurons in the brain which are responsible for synthesis and release of neurotransmitter dopamine.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists

Multipotent stem cells from adult olfactory mucosa

Developmental Dynamics : an Official Publication of the American Association of AnatomistsMarch 23, 2005
Wayne MurrellAlan Mackay-Sim
© 2020 Meta ULC. All rights reserved

Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease

Stem Cells

Jun 7, 2008

Wayne MurrellAlan Mackay-Sim

PMID: 18535154

DOI: 10.1634/stemcells.2008-0074

Abstract

Parkinson's disease is a complex disorder characterized by degeneration of dopaminergic neurons in the substantia nigra in the brain. Stem cell transplantation is aimed at replacing dopaminergic neurons because the most successful drug therapies affect these neurons and their synaptic t...read more

Mentioned in this Paper

Abnormal Degeneration
Neurons
Brain
Stem Cell Transplant
Smell Perception
Substantia Nigra Structure
Olfactory Mucosa
Cell Differentiation Process
Cell Lineage
Neuronal
1
72

Similar Papers Found In These Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Dopamine & Behavior

Dopamine is a neurotransmitter and a hormone commonly associated with the brain's pleasure and reward system. Here is the latest research on its role in affecting and guiding human behaviour.

Related Papers

Developmental Dynamics : an Official Publication of the American Association of Anatomists

Multipotent stem cells from adult olfactory mucosa

Developmental Dynamics : an Official Publication of the American Association of AnatomistsMarch 23, 2005
Wayne MurrellAlan Mackay-Sim
Paper Details
References
  • References51
  • Citations71
12345...
  • References51
  • Citations71
12345...
/papers/olfactory-mucosa-is-a-potential-source-for/18535154