Olfactory mucosal transplantation after spinal cord injury improves voiding efficiency by suppressing detrusor-sphincter dyssynergia in rats

The Journal of Urology
Jiro NakayamaAkihiko Okuyama

Abstract

Several recent studies showed that olfactory mucosal transplantation after spinal cord injury promotes extensive regeneration of the injured spinal cord. We examined the efficacy of olfactory mucosal transplantation for bladder dysfunction after spinal cord injury in rats. In adult female rats the Th9-10 spinal cord was completely transected, followed by olfactory mucosal transplantation or gelatin sponge filling as the control. Each group was examined by cystometrogram and external urethral sphincter electromyogram. Calcitonin gene-related peptide and growth associated protein 43 double positive expression in the L6/S1 dorsal horn was evaluated by immunohistochemistry. Transplant sites were examined by immunohistochemistry with antibodies against neurofilament M and neuronal class III beta-tubulin. On cystometrogram voiding efficiency was significantly higher in the transplantation group than in controls. On external urethral sphincter electromyogram with simultaneous cystometrogram the transplantation group showed a larger ratio of interburst silent periods to burst activity duration and a greater number of high frequency oscillations. In the transplantation group calcitonin gene-related peptide and growth associated protein ...Continue Reading

References

Oct 24, 1998·The Journal of Comparative Neurology·J M HuardJ E Schwob
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·S LiuJ W McDonald
Jun 28, 2002·Neuron·Jin QiuMarie T Filbin
Feb 18, 2004·Nature Neuroscience·Florence M BareyreMartin E Schwab
Oct 4, 2005·Progress in Brain Research·William C de Groat, Naoki Yoshimura
Dec 24, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yolanda Cruz, John W Downie
Jul 22, 2006·Nature Reviews. Neuroscience·Sandrine ThuretFred H Gage
Jul 25, 2006·The Journal of Spinal Cord Medicine·Carlos LimaJean D Peduzzi
Sep 19, 2006·Stem Cells and Development·Soo-Kyung KangCheul-Hong Kim
Mar 16, 2007·Neuroscience Letters·Rosalia PellitteriStefania Stanzani
Apr 21, 2007·Cellular and Molecular Life Sciences : CMLS·D A O'TooleM I Chuah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.