Abstract
Current methods of olfactory sensitivity testing are logistically challenging and therefore infeasible for use in in-home surveys and other field settings. We developed a fast, easy and reliable method of assessing olfactory thresholds, and used it in the first study of olfactory sensitivity in a nationally representative sample of U.S. home-dwelling older adults. We validated our method via computer simulation together with a model estimated from 590 normosmics. Simulated subjects were assigned n-butanol thresholds drawn from the estimated normosmic distribution and based on these and the model, we simulated administration of both the staircase and constant stimuli methods. Our results replicate both the correlation between the two methods and their reliability as previously reported by studies using human subjects. Further simulations evaluated the reliability of different constant stimuli protocols, varying both the range of dilutions and number of stimuli (6-16). Six appropriately chosen dilutions were sufficient for good reliability (0.67) in normosmic subjects. Finally, we applied our method to design a 5-minute, in-home assessment of older adults (National Social Life, Health and Aging Project, or NSHAP), which had compa...Continue Reading
References
Jul 1, 1983·American Journal of Otolaryngology·W S CainR B Goodspeed
Dec 1, 1995·Chemical Senses·R L DotyP Shaman
Feb 1, 1997·Chemical Senses·T HummelG Kobal
Jun 27, 2000·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G KobalT Hummel
Jun 16, 2001·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G KobalT Hummel
Oct 18, 2001·Acta Oto-laryngologica·M WolfensbergerA Welge-Lüssen
Mar 27, 2003·Alcoholism, Clinical and Experimental Research·Claudia I RuppW Wolfgang Fleischhacker
Aug 9, 2003·Chemical Senses·Richard L DotyW William Lee
May 20, 2004·Chemical Senses·Jörn LötschThomas Hummel
Oct 6, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T HummelA Mackay-Sim
Apr 9, 2008·Chemical Senses·Jessica AlbrechtMartin Wiesmann
Oct 22, 2008·Eating Behaviors·Olga PollatosRainer Schandry
Jun 16, 2009·Chemical Senses·Ilona CroyThomas Hummel
Jun 23, 2009·American Journal of Ophthalmology·Catey Bunce
Jun 25, 2009·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·L Philip SchummStacy Tessler Lindau
Jul 2, 2009·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Colm O'MuircheartaighStephen Smith
Sep 18, 2009·Chemical Senses·Antje HaehnerThomas Hummel
Jun 17, 2010·Sexually Transmitted Infections·Phillip J Read, Julie Fox
Jun 24, 2011·Kidney International·Basile N LandisJean-Silvain Lacroix
Jan 30, 2014·Molecular Ecology·Jessica L Waite
Feb 27, 2014·Frontiers in Psychology·Richard L Doty, Vidyulata Kamath
Jun 3, 2014·Chemosensory Perception·Melanie Y DenzerJonathan Beauchamp
Nov 22, 2014·Journal of Health and Social Behavior·Hui Liu, Linda Waite
Nov 1, 2014·Field Methods·David W KernMartha K McClintock
Citations
Jul 26, 2017·Neuroepidemiology·V Eloesa McSorleyDiane S Lauderdale
Mar 31, 2016·Oncotarget·Andrea MazzatentaLuciano Domenici
May 23, 2020·Chemical Senses·Behzad IravaniJohan N Lundström
Jul 17, 2020·Clinical and Experimental Otorhinolaryngology·Jong-Gyun HaChang-Hoon Kim
Jul 2, 2016·HNO·M KühnT Hummel
May 6, 2020·Chemical Senses·Eli P DarnellJayant M Pinto
May 1, 2016·Current Otorhinolaryngology Reports·Jingpu Yang, Jayant M Pinto
May 15, 2020·Chemical Senses·Lucy XuJayant M Pinto
Oct 14, 2020·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Iordanis KonstantinidisSotirios Tsiodras
Oct 22, 2021·Chemical Senses·Emily J Papazian, Jayant M Pinto