PMID: 7544007Aug 15, 1995Paper

Olfactory transduction is intrinsically noisy

Proceedings of the National Academy of Sciences of the United States of America
G Lowe, G H Gold

Abstract

The sources of noise that limit olfactory signal detection were investigated in dissociated rat olfactory receptor cells. Near-threshold odorant-evoked currents exhibited large random fluctuation. However, similar fluctuations were observed in the absence of applied odorants when currents were induced by elevating the intracellular cyclic AMP concentration. This suggests that the fluctuations reflect noise intrinsic to the transduction mechanism, rather than the quantal nature of an odorant stimulus. For many odorants, this intrinsic noise may preclude the reliable detection of single odorant molecules.

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Citations

May 1, 1996·Journal of Neurobiology·D RestrepoD Schild
Mar 1, 1996·Journal of Computational Neuroscience·J P RosparsA Vermeulen
Dec 24, 2005·Journal of Neurocytology·Rebecca Elsaesser, Jacques Paysan
Nov 15, 2012·In Vitro Cellular & Developmental Biology. Animal·Evelien MicholtBart Nicolai
Jan 1, 1996·Genetic Analysis : Biomolecular Engineering·D J FuC R Cantor
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hiroko TakeuchiTakashi Kurahashi
Oct 27, 2010·The Journal of General Physiology·Johannes Reisert
Jun 25, 2005·Science·Vikas BhandawatKing-Wai Yau
Apr 1, 1999·Annual Review of Physiology·G H Gold
Jul 4, 2001·The Journal of Physiology·J Reisert, H R Matthews
Jan 4, 2001·The Journal of Physiology·J Reisert, H R Matthews
Jun 5, 2015·Scientific Reports·Eugenio MartinelliCorrado Di Natale
Sep 23, 2008·The Journal of Comparative Neurology·Fritz W LischkaNancy E Rawson
Apr 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·David ZwickerMichael P Brenner
Nov 12, 2016·PloS One·David Zwicker
Aug 22, 2014·PloS One·Gabriela AntunesFabio Marques Simoes de Souza
Nov 4, 2005·Chemical Senses·Thomas A Cleland, Christiane Linster
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Manoj GopalakrishnanMartin Zapotocky
May 30, 2014·Journal of Neurophysiology·Christopher T FrenzVincent E Dionne
Sep 1, 2008·Journal of Breath Research·A Gelperin, A T C Johnson
Apr 30, 1998·Physiological Reviews·D Schild, D Restrepo
May 20, 2016·Journal of Neurophysiology·Vincent E Dionne

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