OLGA gastritis staging in young adults and country-specific gastric cancer risk

International Journal of Surgical Pathology
M RuggeD Y Graham

Abstract

Geographical differences have been shown in the clinical outcomes of Helicobacter pylori-associated gastritis phenotypes and in gastric cancer risk. This study tested whether the Operative Link on Gastritis Assessment (OLGA) staging correlated with gastric cancer risk in populations from 3 continents. Mapped gastric biopsies were obtained from 316 dyspeptic adults aged less than 41 years from 8 geographic areas that differed in gastric cancer risk. Gastric atrophy was assessed according to internationally validated criteria. Gastritis stage was established according to the OLGA staging system. The most prevalent gastritis stages were 0 to II, which included all subjects entered from Chile, Germany, India, Italy, and Thailand. Gastritis Stages III and IV were limited to the Chinese and Korean populations. Indians had a high prevalence of H pylori infection without high-stage gastritis. In populations at different cancer risk, the gastritis OLGA stage mirrored the gastric cancer incidence. Gastritis staging identifies a subgroup of higher-risk patients.

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Citations

Jan 26, 2011·Journal of Gastroenterology and Hepatology·Duc Trong QuachNaomi Uemura
Dec 8, 2011·World Journal of Gastroenterology : WJG·Massimo RuggeDavid Y Graham
Aug 29, 2013·Gastroenterology Research and Practice·Gonzalo Carrasco, Alejandro H Corvalan
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Apr 7, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo RuggeUNKNOWN Società Italiana di Anatomia Patologica e Citopatologia Diagnostica/International Academy of Pathology, Italian division (SI
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