Oligo Hyaluronan-Coated Silica/Hydroxyapatite Degradable Nanoparticles for Targeted Cancer Treatment

Advanced Science
Yao KangXiaojun Peng

Abstract

Targeted drug delivery systems (TDDSs) provide a promising approach to overcome the side effect of traditional chemotherapy by specific tumor targeting and drug release. Hyaluronan (HA), as a selective CD44 targeting group, has been widely used in TDDSs for chemotherapy. However, different molecular weight HAs would demonstrate different binding ability to CD44, which may result in different therapeutic effects. Herein, a silica/hydroxyapatite (MSNs/HAP) hybrid carrier loaded with anticancer drug doxorubicin (DOX) (DOX@MSNs/HAP) is fabricated. HA and oligo HA (oHA) are coated onto the nanoparticles (HA-DOX@MSNs/HAP, oHA-DOX@MSNs/HAP), respectively, to investigate their performance in tumor targeting ability. oHA-DOX@MSNs/HAP shows much higher efficiency cellular uptake and drug release in tumor regions due to more effective CD44 targeting of oHA. Thus, the anticancer effect of oHA-DOX@MSNs/HAP is significantly enhanced compared to HA-DOX@MSNs/HAP, as demonstrated in a tumor-bearing mouse model. This study may enable the rational design of nanodrug systems for future tumor-targeted chemotherapy.

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Citations

May 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zunfu HuXiuwen Zheng
Jun 6, 2020·Chemical Communications : Chem Comm·Jianjun DuXiaojun Peng
Dec 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shan TaoHong Yuan
Mar 9, 2021·Advanced Materials·Pingping LiangXiaochen Dong
Apr 13, 2021·International Journal of Pharmaceutics·Stefan GrudénMoustapha Hassan

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Methods Mentioned

BETA
transmission
dynamic light scattering
flow cytometry
fluorescence imaging

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