Oligoarginine mediated collagen/chitosan gel composite for cutaneous wound healing

International Journal of Biological Macromolecules
Manman LiLiefeng Zhang

Abstract

In this study, the collagen/chitosan gel composite supplemented with a cell-penetrating peptide (CPP) (Oligoarginine, R8) was prepared. Then, the physicochemical properties of the new collagen/chitosan/CPPs gel obtained were analyzed and the related characteristics were evaluated by scanning electron microscopy (SEM), fourier transform infrared (FTIR), differential scanning calorimetry (DSC), differential thermal analyzer (DTA). Furthermore, we found that collagen/chitosan/CPPs gel composite was capable of inhibiting Staphylococcus aureus growth and had good ability to heal wounds. The mice test results showed that collagen/chitosan/CPPs gel had the highest healing rate, fastest healing speed in all the treatments. After 14 days, the group treated by collagen/chitosan/CPPs gel showed nearly complete wound surface healing rate of 98 ± 4.71%. In addition, histopathological examination suggested that collagen/chitosan/CPPs could promote cutaneous wound healing through enhancing granulation tissue formation, increasing collagen deposition and promoting angiogenesis in the wound tissue. Meanwhile, no significant cytotoxicity of the gel was observed. In conclusion, the collagen/chitosan/CPPs gel composite which has antibacterial acti...Continue Reading

Citations

Mar 11, 2020·Polymers·Andrea Catalina Villamil BallesterosYuli Alexandra Neira Bejarano
Jan 25, 2020·International Journal of Biological Macromolecules·Ponrasu ThangavelSuguna Lonchin
Feb 18, 2021·Carbohydrate Polymers·Sara TorkamanSeyed Heydar Mahmoudi Najafi
Dec 17, 2020·Materials·Ruxandra-Elena Geanaliu-Nicolae, Ecaterina Andronescu
Aug 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yang ZhouJun Wu
Dec 16, 2021·Critical Reviews in Food Science and Nutrition·Zhi-Xiang XiangJin-Song Shi

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