PMID: 69683Jul 1, 1977Paper

Oligoclonal gamma-globulin banding of cerebrospinal fluid in patients with subacute sclerosing panencephalitis. Comparison of the electrophoretic pattern with that in multiple sclerosis and congenital infections

Journal of the Neurological Sciences
H SiemesF Paul

Abstract

Lumbar cerebrospinal fluid (CSF) of 8 patients with subacute sclerosing panencephalitis (SSPE) was examined by agarose gel electrophoresis. In comparison with normal controls and children with different neurological diseases (including infections, tumours and degenerative diseases) the quantitative evaluation of the pherograms by an analog computer revealed an extreme change of the gamma-globulin profile. All cases showed 6-7 abnormal subfractions consisting of 2-4 tall, markedly protruding spikes and several small intermediate fractions. The oligoclonal gamma-globulin contributed 20.1-42.5% to total protein. This particular gamma-globulin profile seems to be highly indicative of the diagnosis of SSPE. It can be distinguished from the oligoclonal pattern in patients suffering from multiple sclerosis (MS) and congenital infections. The CSF protein profile of 13 patients with MS was different from that in SSPE in that it showed 1-5 monoclonal gamma-fractions in every case with none or only one peak protuding more markedly. The percentage of all subfractions amounted to 4.5-23.8% of total protein. As in MS, the aspect of oligoclonality in 9 children with congenital infections (cytomegalic inclusion body disease, toxoplasmosis and ...Continue Reading

References

May 8, 1975·The New England Journal of Medicine·R T Johnson
May 1, 1972·Journal of the Neurological Sciences·H Link
Jan 1, 1974·Scandinavian Journal of Immunology·M Sandberg-Wollheim
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B Vandvik, E Norrby
May 15, 1972·JAMA : the Journal of the American Medical Association·J T JabbourL Horta-Barbosa
Oct 1, 1971·Archives of Neurology·H Link, R Müller
Apr 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·H H KREUTZER, W H FENNIS
Apr 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·L M WEINER, B ZAK
Aug 1, 1968·Journal of Neurochemistry·L BergmannL Svennerholm

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