PMID: 9191874May 1, 1997Paper

Oligoclonal in vitro response of CD4 T cells to vesicles of mistletoe extracts in mistletoe-treated cancer patients

Cancer Immunology, Immunotherapy : CII
S FischerDieter Kabelitz

Abstract

Mistletoe (Viscum album) extracts are widely used in adjuvant cancer therapy. We have investigated the in vitro responsiveness of T cells from mistletoe-treated cancer patients and untreated healthy donors to various preparations of mistletoe extracts. Proliferation of peripheral blood mononuclear cells from treated but not from untreated patients was observed in response to therapeutically used mistletoe extracts prepared from apple (mali) or pine (pini) host trees. The strongest proliferation was induced by a vesicle preparation of mali extract. Activation was strongly inhibited by interleukin-10. Using a newly developed flow-cytometry assay, we determined that cell growth was restricted to CD4 T cells. Analysis with a panel of monoclonal antibodies against the variable region of the T cell receptor beta chain (V beta) revealed an oligoclonal pattern of CD4 T cell activation. These results indicate that therapeutic administration of mistletoe extracts sensitizes a restricted set of CD4 T lymphocytes in mistletoe-treated patients.

Citations

Jan 8, 1999·Biochimica Et Biophysica Acta·G M SteinA Büssing
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M Stein, P A Berg
Mar 5, 2003·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Roman HuberMichael Werner
Oct 21, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Angelika Kirsch, Tibor Hajto
Nov 27, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Tibor HajtóPèter Németh
Jul 28, 2004·Journal of Herbal Pharmacotherapy·Sonja FischerArmin Scheffler
Aug 30, 2005·Colloids and Surfaces. B, Biointerfaces·Karin WinklerRolf Schubert

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