PMID: 3770998Nov 15, 1986Paper

Oligoclonal tumours

International Journal of Cancer. Journal International Du Cancer
M F WoodruffR B Potts

Abstract

Tumours are commonly classified as monoclonal or polyclonal. The question of how many clones are present in a polyclonal tumour is seldom asked; it is important, however, because the answer may show whether or not clones arise and develop independently, and whether the number of clones in tumours of a particular kind tends to increase or decrease with time. We have used two procedures to assess the clonality of chemically-induced murine fibrosarcomas, one based on the heterozygosity of the tumour hosts for an X-linked marker, the other on the expression of tumour-associated transplantation antigens (TATA) by the tumours. As we have reported previously, many of these tumours are pleoclonal. Evidence now presented suggests that the clones do not develop independently and that many of the tumours are biclonal.

References

Oct 1, 1979·The Journal of Experimental Medicine·A L Reddy, P J Fialkow
Feb 15, 1986·International Journal of Cancer. Journal International Du Cancer·F D DeamantP M Iannaccone
Feb 1, 1985·Genetical Research·L M Forrester, J D Ansell
Jul 4, 1974·The New England Journal of Medicine·P J Fialkow
Jul 5, 1984·The New England Journal of Medicine·J SklarR Levy
Dec 1, 1984·Cancer Genetics and Cytogenetics·E Gödde-Salz, E W Schwarze
Oct 28, 1982·Nature·M F WoodruffH S Micklem

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Citations

Dec 1, 1987·Cancer Treatment Reviews·D R Welch
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K YamadaT Hayakawa

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