Oligodendrocyte- and Neuron-Specific Nogo-A Restrict Dendritic Branching and Spine Density in the Adult Mouse Motor Cortex

Cerebral Cortex
Ajmal ZemmarMartin E Schwab

Abstract

Nogo-A has been well described as a myelin-associated inhibitor of neurite outgrowth and functional neuroregeneration after central nervous system (CNS) injury. Recently, a new role of Nogo-A has been identified as a negative regulator of synaptic plasticity in the uninjured adult CNS. Nogo-A is present in neurons and oligodendrocytes. However, it is yet unclear which of these two pools regulate synaptic plasticity. To address this question we used newly generated mouse lines in which Nogo-A is specifically knocked out in (1) oligodendrocytes (oligoNogo-A KO) or (2) neurons (neuroNogo-A KO). We show that both oligodendrocyte- and neuron-specific Nogo-A KO mice have enhanced dendritic branching and spine densities in layer 2/3 cortical pyramidal neurons. These effects are compartmentalized: neuronal Nogo-A affects proximal dendrites whereas oligodendrocytic Nogo-A affects distal regions. Finally, we used two-photon laser scanning microscopy to measure the spine turnover rate of adult mouse motor cortex layer 5 cells and find that both Nogo-A KO mouse lines show enhanced spine remodeling after 4 days. Our results suggest relevant control functions of glial as well as neuronal Nogo-A for synaptic plasticity and open new possibilit...Continue Reading

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Citations

Aug 10, 2017·Journal of Neuropathology and Experimental Neurology·Daniel J ShepherdGwendolyn L Kartje
Sep 1, 2020·Investigative Ophthalmology & Visual Science·Zongyi ZhanMinbin Yu
Aug 28, 2020·Frontiers in Cellular Neuroscience·Steven PetratosJae Young Lee
Aug 14, 2020·Neural Regeneration Research·Yang-Yang WangJun Zhang
Jul 10, 2019·Annual Review of Neuroscience·Daniel K WiltonBeth Stevens
Aug 6, 2020·International Journal of Molecular Sciences·Vini NagarajMelitta Schachner
Oct 14, 2020·Nature Reviews. Neuroscience·Wendy Xin, Jonah R Chan
Apr 9, 2021·The European Journal of Neuroscience·Vishal ChavdaBipin Chaurasia
Aug 8, 2021·International Journal of Molecular Sciences·Megan ChesnutDavid Pamies
Dec 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Melanie J GrubishaRobert A Sweet

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