Oligodendrocyte precursors migrate along vasculature in the developing nervous system

Science
Hui-Hsin TsaiStephen P J Fancy

Abstract

Oligodendrocytes myelinate axons in the central nervous system and develop from oligodendrocyte precursor cells (OPCs) that must first migrate extensively during brain and spinal cord development. We show that OPCs require the vasculature as a physical substrate for migration. We observed that OPCs of the embryonic mouse brain and spinal cord, as well as the human cortex, emerge from progenitor domains and associate with the abluminal endothelial surface of nearby blood vessels. Migrating OPCs crawl along and jump between vessels. OPC migration in vivo was disrupted in mice with defective vascular architecture but was normal in mice lacking pericytes. Thus, physical interactions with the vascular endothelium are required for OPC migration. We identify Wnt-Cxcr4 (chemokine receptor 4) signaling in regulation of OPC-endothelial interactions and propose that this signaling coordinates OPC migration with differentiation.

References

Oct 9, 1992·Science·N A O'RourkeS K McConnell
May 20, 1994·Science·C Lois, A Alvarez-Buylla
Feb 15, 2001·Nature Neuroscience·B NadarajahA L Pearlman
Apr 2, 2003·Development·Hui-Hsin TsaiRobert H Miller
Mar 5, 2004·Development·Kelly A HoganVictoria L Bautch
Jan 3, 2006·Nature Neuroscience·Nicoletta KessarisWilliam D Richardson
Aug 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuki MiyamotoAkito Tanoue
Oct 22, 2008·Nature Reviews. Neuroscience·Robin J M Franklin, Charles Ffrench-Constant
Jan 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard DanemanBen A Barres
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marina SnapyanArmen Saghatelyan
Jun 12, 2009·Genes & Development·Stephen P J FancyDavid H Rowitch
Feb 24, 2010·Carcinogenesis·Els C Robanus-MaandagRon Smits
Jun 28, 2011·Nature Neuroscience·Stephen P J FancyDavid H Rowitch
Oct 28, 2011·Nature Neuroscience·Steven A Goldman, Zhuoxun Chen
May 25, 2012·Nature·Ursula FünfschillingKlaus-Armin Nave
Jun 30, 2012·Science·Hui-Hsin TsaiDavid H Rowitch
Jul 18, 2012·Nature·Youngjin LeeJeffrey D Rothstein
Jun 28, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fabien BinaméJacqueline Trotter
Mar 13, 2014·Nature Neuroscience·Stephen P J FancyDavid H Rowitch
Jan 6, 2015·Cell Reports·Ekaterina PosokhovaBrad St Croix

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Citations

Jan 23, 2016·Science·Elisabetta Dejana, Christer Betsholtz
Apr 28, 2016·Acta Neuropathologica Communications·Xiaoming YaoA S Verkman
Apr 30, 2016·Current Opinion in Neurobiology·Sonia R Mayoral, Jonah R Chan
Apr 30, 2016·Current Opinion in Neurobiology·Anne-Laure Cattin, Alison C Lloyd
May 7, 2016·Current Opinion in Neurobiology·Ethan G Hughes, Bruce Appel
Jun 11, 2016·Science·Sueli MarquesGonçalo Castelo-Branco
Jul 16, 2016·The Journal of Comparative Neurology·Catherine CzeislerJosé Javier Otero
Oct 25, 2016·Trends in Pharmacological Sciences·Amit MoghaKelly R Monk
Aug 5, 2016·Journal of Stroke·Zhenggang Zhang, Michael Chopp
Oct 8, 2016·PloS One·Rafael Almeida, David Lyons
Nov 10, 2016·Behavioural Brain Research·Hajime TakaseJosephine Lok
Nov 24, 2016·International Journal of Molecular Sciences·Bangfu ZhuBing Song
Jan 28, 2017·Expert Review of Neurotherapeutics·Ethan HollingsworthJaime Imitola
Mar 7, 2017·Nature Communications·Patricia HimmelsCarmen Ruiz de Almodóvar
Mar 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bongnam JungChrister Betsholtz
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Shoujun ZhuHongjie Dai
Jul 8, 2017·Nature Reviews. Drug Discovery·Jason R PlemelV Wee Yong
Aug 24, 2017·Brain Pathology·Maria ThomEleonora Aronica
Nov 11, 2017·Frontiers in Neuroscience·Xi ChengWeiyu Teng
Nov 25, 2017·Neural Regeneration Research·Jessie NewvilleLee Anna Cunningham
Jul 10, 2018·Annual Review of Neuroscience·Michelle Monje
Aug 24, 2018·Developmental Neurobiology·Ashley N BrandeburaGeorge A Spirou
Jun 20, 2018·International Immunology·Shogo Tanabe, Toshihide Yamashita
Nov 11, 2018·International Journal of Cancer. Journal International Du Cancer·Maria Laura FalchettiRoberto Pallini
Mar 4, 2018·Acta Neuropathologica Communications·Sara E NasrabadyAdam M Brickman
Mar 8, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masato KanazawaGregory J Del Zoppo
Mar 16, 2019·Nature Reviews. Neuroscience·Carla G SilvaLaurent Nguyen
Mar 9, 2019·Annals of Neurology·Martina AbsintaDaniel S Reich
Apr 26, 2019·Journal of the American Heart Association·Natsue KishidaRyosuke Takahashi
Jun 19, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Max I BogoradPeter C Searson
Jul 5, 2019·Journal of Cellular Biochemistry·Lihui LanChenghai Zhao
Aug 15, 2019·CNS Neuroscience & Therapeutics·Minkyung Kang, Yao Yao
Mar 9, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shogo Tanabe, Toshihide Yamashita
Dec 18, 2019·Médecine sciences : M/S·Camille SautreuilBruno J Gonzalez
Oct 20, 2019·Cellular and Molecular Life Sciences : CMLS·Charlotte G H M de JongWia Baron
Aug 20, 2017·Cellular and Molecular Life Sciences : CMLS·Shwetal Mehta, Costanza Lo Cascio
Jun 17, 2020·PLoS Genetics·Bernardo Blanco-SánchezMonte Westerfield
Jun 9, 2020·International Journal of Cancer. Journal International Du Cancer·Erik JungFrank Winkler

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