PMID: 8586995Oct 1, 1995Paper

Oligodendrocyte survival and function in the long-lived strain of the myelin deficient rat

Journal of Neurocytology
I D DuncanM R Wells

Abstract

This study has examined cellular and molecular aspects of glial cell function in a newly described long-lived myelin deficient rat mutant. In contrast to the shorter-lived mutants which died at 25-30 days, the longer-lived mutant rats lived to 75-80 days of age. Despite living longer, these mutants had a similar frequency of seizures to their younger counterparts. In the spinal cord and optic nerves of the older mutants, myelinated fibres in similar numbers to those seen in the younger myelin deficient rats were present. However, the total glial cell numbers were markedly reduced with few remaining normal appearing oligodendrocytes, and very few microglia compared to the younger mutants. In addition, little or no cell death or division was seen in the longer-lived rats. However, there was some evidence of ongoing myelination and the persistence of immature oligodendrocytes or their progenitors in the older mutant. There was some continued myelin gene expression, although this was at much reduced levels compared to normal, with proteolipid protein and myelin basic protein being most affected. In situ hybridization analysis for proteolipid protein mRNA showed that few proteolipid protein expressing oligodendrocytes remained in th...Continue Reading

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Citations

Oct 8, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ian D DuncanSu-Chun Zhang
Jan 1, 1997·Journal of Anatomy·I D Duncan, R L Hoffman
Apr 1, 1996·Neuropathology and Applied Neurobiology·I D Duncan
Jul 1, 1995·Brain Pathology·I D Duncan, E A Milward
Apr 14, 2016·Experimental Neurology·Ian D Duncan, Abigail B Radcliff
Jul 22, 1998·Microscopy Research and Technique·I GriffithsK A Nave
Feb 6, 2018·Acta Neuropathologica·Alessandra DillenburgVeronique E Miron
Oct 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·I R Griffiths
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Mar 20, 2003·Journal of Neuroscience Research·K Al-SaktawiI R Griffiths
Oct 19, 2016·Journal of Neuroscience Research·Antoine Marteyn, Anne Baron-Van Evercooren
Mar 10, 1999·Methods : a Companion to Methods in Enzymology·R J Franklin, W F Blakemore

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