Oligodendrocytes as providers of growth factors

Journal of Neuroscience Research
Yangzhou Du, C F Dreyfus

Abstract

Glial cells recently are being appreciated as supporters of brain neurons. This review addresses their role as growth factor providers. While the function of astrocytes in this capacity is known, new data indicate that oligodendrocytes, the myelinating cells of the brain, exhibit similar abilities. Oligodendrocytes provide trophic signals to nearby neurons and synthesize defined growth factors. Expression of growth factors is influenced by neural signals. The review summarizes these roles and their implications in brain function.

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Related Concepts

Insulin-Like Growth Factor I
Transforming Growth Factor beta
Epidermal Growth Factor
Neurons
Brain
Astrocytes
Paracrine Protein Factors
Neuronal Differentiation Factor, Cholinergic
Neuroglia
Growth Substances

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