Oligodendrocytes express a normal phenotype in carbonic anhydrase II-deficient mice

Journal of Neuroscience Research
M S GhandourR E Tashian

Abstract

The nervous system of a mouse mutant characterized by a carbonic anhydrase II (CA II) deficiency was examined with light and electron microscopy and with immunocytochemistry using different glial cell markers. No major morphologic abnormalities at either the cellular or subcellular level are detectable in the brains of CAII-deficient mice, even though CAII is the main isozyme of CA in the brain. The oligodendrocytes, which characteristically express high levels of CA II, do not exhibit signs of degeneration or abnormalities even in 1-year-old CA II-deficient mice. Similarly, neurons and astrocytes have a normal structure and distribution. Oligodendrocytes show a normal staining pattern and distribution for galactocerebroside (GC), 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP), and myelin basic protein (MBP). Astrocytes have a normal morphology and distribution when stained for GFAP and S100 protein. The lack of major degeneration in the brain due to a CA II deficiency suggests these mice utilize other enzymatic or physiological pathways to compensate for the enzyme absence.

References

Dec 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M S GhandourG Gombos
Jun 1, 1989·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R E Tashian
Oct 1, 1988·Journal of Applied Physiology·S J DodgsonR E Tashian
Jan 1, 1988·Journal of Neurochemistry·W Cammer, F A Tansey
Jul 1, 1988·Journal of Neuroimmunology·C Griot, M Vandevelde
Apr 19, 1988·Biochemistry·R T FernleyJ P Coghlan
Aug 1, 1988·Journal of Neurocytology·M S Ghandour, R P Skoff
Jan 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W CammerV Sapirstein
Nov 1, 1972·Biological Reviews of the Cambridge Philosophical Society·M J Carter
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jul 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T KumpulainenS H Nyström
Jul 1, 1980·The Histochemical Journal·O K LangleyG Gombos
Sep 7, 1981·Brain Research·T Kumpulainen, S H Nyström

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Citations

Feb 15, 1995·Journal of Neuroscience Research·M Taniike, K Suzuki
Jan 1, 1993·Journal of Inherited Metabolic Disease·S AramakiF Yamashita
Aug 1, 1993·Journal of the Neurological Sciences·W CammerM Cammer
Apr 16, 1993·Brain Research. Developmental Brain Research·L VelíŝekW Cammer
Jan 1, 1993·Journal of Neuroimmunology·A da CunhaL Vitković
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M S GhandourW S Sly
Feb 28, 2002·Molecular and Cellular Neurosciences·Laurence DeckerAnne Baron-Van Evercooren
Nov 6, 2003·The Journal of Biological Chemistry·Jonna LehtonenSeppo Parkkila
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Elizabeth KidaKrystyna E Wisniewski
Apr 24, 1995·The Journal of Comparative Neurology·R P Skoff, M S Ghandour

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