Oligodendrocytes within astrocytes ("emperipolesis") in the white matter in Creutzfeldt-Jakob disease

Acta Neuropathologica
Masayuki Shintaku, Chikao Yutani

Abstract

The occurrence of oligodendrocytes within astrocytes ("emperipolesis") has been described in demyelinating lesions in cases of multiple sclerosis and also in other non-demyelinating disorders. We found that this finding was common in the cerebral white matter of patients with Creutzfeldt-Jakob disease (CJD). Eight consecutive autopsy cases of sporadic CJD were reviewed, and in every case the gray matter exhibited classical histopathological features of CJD. In five cases with a long clinical course, the cerebral white matter was severely involved, and both axons and myelin sheaths were lost markedly. Within this devastated white matter, many hypertrophic astrocytes were found to engulf one to several oligodendrocytes within their cytoplasm (emperipolesis). The oligodendroglial nature of the engulfed cells was corroborated by nuclear immunoreactivity for anti-human Olig 2 antibody. In the remaining three cases, whose clinical course was short, the cerebral white matter was relatively well preserved, and emperipolesis was not or only very rarely found. The prevalence of emperipolesis of this type in the white matter in CJD was well correlated with the severity of the white matter lesions.

Citations

Dec 17, 2009·Acta Neuropathologica·Michael V Sofroniew, Harry V Vinters
Mar 9, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Makoto NishieKoichi Wakabayashi
Jun 15, 2006·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Li ChenDe-Hong Lu
Feb 6, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akira HoshinoKo Sahashi
Nov 22, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Annette Persson, Elisabet Englund
Apr 11, 2009·Brain : a Journal of Neurology·Alessia MelaniFelicita Pedata
May 9, 2009·Medical Hypotheses·Annette Persson, Elisabet Englund
May 11, 2016·Ultrastructural Pathology·Jacques GilloteauxJack L Summers
Dec 8, 2007·Diagnostic Cytopathology·Stine-Kathrein KraeftSavitri Krishnamurthy
Sep 12, 2008·Nature Reviews. Molecular Cell Biology·Michael Overholtzer, Joan S Brugge
Mar 29, 2020·The Journal of Experimental Medicine·Beatrice WasserStefan Bittner
Mar 10, 2019·Biochemical Society Transactions·Hannah L Mackay, Patricia A J Muller
Jan 27, 2021·The Journal of Comparative Neurology·Karthik RaviArumugam R Jayakumar
May 1, 2021·International Journal of Molecular Sciences·Katrina AlbertŠárka Lehtonen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Bovine Spongiform Encephalopathy (MDS)

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Bovine Spongiform Encephalopathy

Bovine spongiform encephalopathy is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Journal of Neuropathology and Experimental Neurology
N R Ghatak
Acta Neuropathologica
Michael V Sofroniew, Harry V Vinters
Neuropathology : Official Journal of the Japanese Society of Neuropathology
Makoto NishieKoichi Wakabayashi
© 2022 Meta ULC. All rights reserved