Abstract
We report the occurrence of oligodendrocytes within astrocytes ("emperipolesis") in two autopsy cases of metabolic encephalopathy: one patient with hepatic encephalopathy due to citrullinemia who suffered recurrent unconsciousness (clinical duration, 32 months) and another with hypoglycemic encephalopathy who lapsed into a persistent vegetative state (clinical duration, 22 months). In both cases, hypertrophic astrocytes were found to have engulfed one to several oligodendrocytes in the devastated cerebral white matter. Previous studies have reported that emperipolesis occurs in various CNS diseases showing destruction of myelin or inflammation of the white matter, including multiple sclerosis, cerebral infarct and CJD. The present findings suggest that emperipolesis can occur even in chronic metabolic disorders that extensively involve the cerebral white matter.
References
Jan 1, 1992·Journal of Neuropathology and Experimental Neurology·N R Ghatak
Apr 1, 1970·American Journal of Clinical Pathology·T E Larsen
Jan 1, 1982·Acta Neuropathologica·J J MartinP De Jonghe
Jan 1, 1994·Annals of Neurology·D L YaoS Komoly
Jan 1, 1993·Journal of Neurochemistry·M TakahashiK Imahori
Mar 17, 2000·Neuron·Q R LuD H Rowitch
Mar 17, 2000·Neuron·Q ZhouD J Anderson
Oct 29, 2000·Neuropathology and Applied Neurobiology·D DolinakD I Graham
Mar 27, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·J A AndrikoR V Jones
Mar 29, 2001·Microscopy Research and Technique·M Wegner
Jul 3, 2002·Biochemistry·Emma HlavandaJudit Ovádi
Jul 1, 1956·British Journal of Haematology·J G HUMBLER J PULVERTAFT
Apr 28, 2004·The American Journal of Pathology·Hideaki YokooYoichi Nakazato
Jul 6, 2004·Acta Neuropathologica·Masayuki Shintaku, Chikao Yutani
Oct 12, 2004·Neurobiology of Disease·Gábor G KovácsJudit Ovádi
Dec 14, 2004·The Journal of Biological Chemistry·Evo LinderssonPoul Henning Jensen
Citations
Nov 24, 2006·Acta Neuropathologica·Gábor G KovácsJudit Ovádi
Sep 12, 2008·Nature Reviews. Molecular Cell Biology·Michael Overholtzer, Joan S Brugge
Mar 31, 2012·PloS One·Camilla LöövAnna Erlandsson
Nov 19, 2013·Journal of the American Academy of Dermatology·Tsai-Ching ChouChih-Hung Lee
Mar 17, 2010·Molecular Genetics and Metabolism·Olivier Braissant
Sep 21, 2007·Brain Research Reviews·Laurène Cagnon, Olivier Braissant
Dec 8, 2007·Diagnostic Cytopathology·Stine-Kathrein KraeftSavitri Krishnamurthy
Apr 3, 2008·The European Journal of Neuroscience·Olivier BraissantHugues Henry
May 11, 2016·Ultrastructural Pathology·Jacques GilloteauxJack L Summers