PMID: 9633812Jun 20, 1998Paper

Oligodendroglial reaction following spinal cord injury in rat: transient upregulation of MBP mRNA

Glia
D Bartholdi, M E Schwab

Abstract

The reaction of oligodendrocytes in response to traumatic injury of the CNS are poorly understood. In the present report we studied changes in the expression of a major constituent of CNS myelin, myelin basic protein (MBP), by immunohistochemistry and in situ hybridization from 6 h up to 2 weeks following partial transection of the spinal cord in adult rats. MBP immunohistochemistry showed degeneration of myelin at the lesion center and signs of myelin breakdown in necrotic foci in the dorsal and ventral funiculi proximal and distal to the lesion. In situ hybridization revealed that mRNA for MBP was downregulated at the local lesion site within the first day following injury, probably reflecting oligodendrocytes to undergo cell death. From 2 days on, however, MBP mRNA was conspicuously upregulated at the border of the lesion area. This "reactive" response of surviving oligodendrocytes, as indicated by increased levels of MBP mRNA, peaked around 8 days. At this time, oligodendrocytes displaying strong MBP in situ signal formed stripe-like structures which were oriented radially toward the lesion center and arranged in parallel to neurofilament-positive axons. At around 2 weeks post-injury, MBP mRNA at the border of the lesion ar...Continue Reading

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Citations

Jan 29, 2000·Microscopy Research and Technique·J WeiseM Bähr
Sep 11, 2001·Journal of Neuroscience Research·K IshiiK Uyemura
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S WoerlyA Espinosa
Mar 20, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R P SkoffF S Silverstein
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M B JensenB Finsen
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J GuanA J Gunn
Dec 4, 2003·Journal of Neuroscience Research·Lara T DiemelM Louise Cuzner
Aug 9, 2006·Journal of Neurochemistry·Ming Cheng LiuKevin K W Wang
Jul 23, 2008·Journal of Neurochemistry·Dana M McTigue, Richa B Tripathi
Aug 23, 2005·Brain Research. Brain Research Reviews·Jan M SchwabAlain Chédotal
Jan 18, 2014·Developmental Cell·Amanda Brosius Lutz, Ben A Barres
Jul 25, 2019·Glia·Jillian BelgradRichard Douglas Fields
Apr 18, 2009·Cell Adhesion & Migration·Sei ShibuyaToshifumi Itano

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