Oligodendroglioma resection: a Surveillance, Epidemiology, and End Results (SEER) analysis

Journal of Neurosurgery
Ali A AlattarClark C Chen

Abstract

OBJECTIVE The available evidence suggests that the clinical benefits of extended resection are limited for chemosensitive tumors, such as primary CNS lymphoma. Oligodendroglioma is generally believed to be more sensitive to chemotherapy than astrocytoma of comparable grades. In this study the authors compare the survival benefit of gross-total resection (GTR) in patients with oligodendroglioma relative to patients with astrocytoma. METHODS Using the Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database, the authors identified 2378 patients with WHO Grade II oligodendroglioma (O2 group) and 1028 patients with WHO Grade III oligodendroglioma (O3 group). Resection was defined as GTR, subtotal resection, biopsy only, or no resection. Kaplan-Meier and multivariate Cox regression survival analyses were used to assess survival with respect to extent of resection. RESULTS Cox multivariate analysis revealed that the hazard of dying from O2 and O3 was comparable between patients who underwent biopsy only and GTR (O2: hazard ratio [HR] 1.06, 95% confidence interval [CI] 0.73-1.53; O3: HR 1.18, 95% CI 0.80-1.72). A comprehensive search of the published literature identified 8 articles without compelling evidence t...Continue Reading

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Citations

Mar 21, 2019·Cancer·Chelsea AndersonHazel B Nichols
May 18, 2019·American Society of Clinical Oncology Educational Book·Martin C TomJennifer S Yu
Aug 16, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Kenney Roy RoodakkerAnja Smits
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Mar 14, 2021·Annales de pathologie·Alice Métais, Audrey Rousseau

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Stata SE

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