PMID: 9526834Apr 4, 1998Paper

Oligofructose modulates lipid metabolism alterations induced by a fat-rich diet in rats

Journal of Applied Toxicology : JAT
N KokNathalie M Delzenne

Abstract

The aim of this study was to test the hypothesis that non-digestible fructans, namely oligofructose (OFS), are able to decrease post-prandial lipaemia in rats fed a high-fat diet composed of 10% lard, 4% corn oil and 0.15% cholesterol. Male Wistar rats were divided into three groups: group 1 was fed a standard low-fat diet (AO4), group 2 received the high-fat diet (HF) and group 3 received 10% (w/w) OFS in the HF diet (HF-OFS) for 3 weeks. The OFS supplementation reduced post-prandial triglyceridaemia by more than 50%, compared to both AO4 and HF groups. It also protected rats against the increase in free cholesterol serum level induced by the HF diet. The OFS did not prevent the HF-induced hepatic accumulation of triglycerides, phospholipids and cholesterol; however, histochemical analysis showed smaller lipid droplets in the liver of HF-OFS rats as compared to HF rats. Our results suggest that, when given in HF diet, OFS decreases serum triglycerides through an extra-hepatic event, namely by enhancing triglyceride-rich lipoprotein catabolism.

Citations

Mar 6, 2004·Journal of Physiology and Biochemistry·J BoucherP Valet
Feb 2, 2010·Journal of Physiology and Biochemistry·M Sabater-MolinaS Zamora
Jul 27, 2010·Fish Physiology and Biochemistry·Seyed Hossein HoseinifarKazem Darvish Bastami
Sep 1, 2012·Nutrition Research·Damien P BelobrajdicAnthony R Bird
Nov 5, 2015·Current Opinion in Pharmacology·Ana Luisa NevesMarc-Emmanuel Dumas
Jul 23, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Frances G BoyleEric L Lien
Jan 10, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Jill A ParnellRaylene A Reimer
Oct 11, 2005·The Journal of Nutritional Biochemistry·Soon Ah KangYoongho Lim
Oct 6, 2010·The British Journal of Nutrition·Marcel RoberfroidAgnes Meheust
May 17, 2003·The Proceedings of the Nutrition Society·N M Delzenne
Dec 30, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Omotayo O ErejuwaMohd S Ab Wahab
Aug 23, 2007·The British Journal of Nutrition·Judith E Urías-SilvasNathalie M Delzenne
Apr 15, 2008·The British Journal of Nutrition·Pascale RozanMichaël Messaoudi
Dec 1, 2004·Nutrition Research Reviews·Glenn R GibsonMarcel B Roberfroid
Feb 7, 2001·The American Journal of Clinical Nutrition·N M Delzenne, N Kok
Jul 25, 2009·Medicinski pregled·Zdenka B SokiićMiroslav M Vrvić
May 10, 2005·The British Journal of Nutrition·Michel Beylot
May 10, 2005·The British Journal of Nutrition·Rémy Burcelin
Oct 8, 2008·Journal of Agricultural and Food Chemistry·Megumi NishimukaiSusumu Ito

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