Oligogalacturonic Acid Inhibits Vascular Calcification by Two Mechanisms: Inhibition of Vascular Smooth Muscle Cell Osteogenic Conversion and Interaction With Collagen

Arteriosclerosis, Thrombosis, and Vascular Biology
Ahmed HodrogeJérôme Ausseil

Abstract

Cardiovascular diseases constitute the leading cause of mortality worldwide. Calcification of the vessel wall is associated with cardiovascular morbidity and mortality in patients having many diseases, including diabetes mellitus, atherosclerosis, and chronic kidney disease. Vascular calcification is actively regulated by inductive and inhibitory mechanisms (including vascular smooth muscle cell adaptation) and results from an active osteogenic process. During the calcification process, extracellular vesicles (also known as matrix vesicles) released by vascular smooth muscle cells interact with type I collagen and then act as nucleating foci for calcium crystallization. Our primary objective was to identify new, natural molecules that inhibit the vascular calcification process. We have found that oligogalacturonic acids (obtained by the acid hydrolysis of polygalacturonic acid) reduce in vitro inorganic phosphate-induced calcification of vascular smooth muscle cells by 80% and inorganic phosphate-induced calcification of isolated rat aortic rings by 50%. A specific oligogalacturonic acid with a degree of polymerization of 8 (DP8) was found to inhibit the expression of osteogenic markers and, thus, prevent the conversion of vasc...Continue Reading

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Citations

Apr 16, 2019·Current Opinion in Nephrology and Hypertension·Jakob VoelklIoana Alesutan
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong S LuAlan Daugherty
Mar 28, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Congqing WuHong S Lu
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Dec 18, 2020·Frontiers in Cell and Developmental Biology·Ali MansourJérôme Ausseil
May 11, 2021·Frontiers in Cardiovascular Medicine·Wenhong JiangXiao Qin

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