Oligohydramnios and pulmonary hypoplasia: a case in which involvement of an angiotensin II receptor antagonist was suspected

The Journal of Obstetrics and Gynaecology Research
Kaoru KatoFumiki Hirahara

Abstract

Administration of an angiotensin II receptor antagonist (ARB) during the second trimester of pregnancy is known to cause irreversible renal damage in the fetus. We report a case in which ARB was given to the mother from the first trimester until 26 weeks' gestation. The patient had diabetic nephropathy with accompanying nephrotic syndrome. At 8 weeks' gestation, she was started on candesartan cilexetil (an ARB). At 26 weeks' gestation, she was transferred to our center. Severe oligohydramnios was noted. The pregnancy was terminated, and she delivered at 27 weeks' gestation. The neonate weighed 884 g and died 1 h after birth. Autopsy revealed that the lung/bodyweight ratio was 0.0096 (>0.015) and pulmonary hypoplasia was noted. Histological examination of the kidneys showed tubular dysgenesis with poor differentiation of the proximal tubules.

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Citations

Jul 21, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Camilla BorthenJan Schjøtt
Jan 12, 2010·The Journal of Headache and Pain·Kirsti Haaland
Jan 25, 2013·International Journal of Hypertension·M RodriguezJ Hasbun
Feb 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chisa ShimadaHisanori Minakami
Jun 12, 2010·Cardiology in Review·Belinda JimAnjali Acharya

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