Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease.

Neurobiology of Disease
Cristina AgliardiMario Clerici

Abstract

Blood-based biomarkers are needed to be used as easy, reproducible, and non-invasive tools for the diagnosis and prognosis of chronic neurodegenerative disorders including Parkinson's Disease (PD). In PD, aggregated toxic forms of α-Synuclein (α-Syn) accumulate within neurons in the brain and cause neurodegeneration; α-Syn interaction with SNARE proteins also results in synaptic disfunction. We isolated neural derived extravesicles (NDEs) from peripheral blood of 32 PD patients and 40 healthy controls (HC) and measured the concentrations of oligomeric α-Syn and of the presinaptic SNARE complex proteins: STX-1A, VAMP-2 and SNAP-25. Oligomeric α-Syn was significantly augmented whereas STX-1A and VAMP-2 were significantly reduced in NDEs of PD patients compared to HC (p < 0.001 in all cases). ROC curve analyses confirmed the discriminatory ability of NDEs oligomeric α-Syn, STX-1A and VAMP-2 levels to distinguish between PD patients and HC. Oligomeric α-Syn NDEs concentration also positively correlated with disease duration and severity of PD. These results are promising and confirm that NDEs cargoes likely reflect core pathogenic intracellular processes in their originating brain cells and could serve as novel easily accessible bi...Continue Reading

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Citations

May 1, 2021·Cells·Azzurra Margiotta
Jul 3, 2021·International Journal of Molecular Sciences·Alessandra MingionePaola Signorelli
Jul 13, 2021·Frontiers in Aging Neuroscience·Nelson de Oliveira ManzanzaRaj N Kalaria
Jul 25, 2021·International Journal of Molecular Sciences·Isaac DengLarisa Bobrovskaya
Aug 28, 2021·Biomedicines·Maria I Mosquera-HerediaPilar Garavito-Galofre

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