Oligometastases in prostate cancer: Ablative treatment

World Journal of Clinical Oncology
Amalia Palacios-EitoSonia García-Cabezas

Abstract

Technological advances in radiotherapy have led to the introduction of techniques such as stereotactic body radiation therapy (SBRT), allowing the administration of ablative doses. The hypothesis that oligometastatic disease may be cured through local eradication therapies has led to the increasing use of SBRT in patients with this type of disease. At the same time, scientific advances are being made to allow the confirmation of clinically suspected oligometastatic status at molecular level. There is growing interest in identifying patients with oligometastatic prostate cancer (PCa) who may benefit from curative intent metastasis-directed therapy, including SBRT. The aim is to complement, replace or delay the introduction of hormone therapy or other systemic therapies. The present review aims to compile the evidence from the main ongoing studies and results on SBRT in relation to oligometastatic PCa; examine aspects where gaps in knowledge or a lack of consensus persist (e.g., optimum schemes, response assessment, identification and diagnosis of oligometastatic patients); and document the lack of first-level evidence supporting the use of such techniques.

References

Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Hellman, R R Weichselbaum
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Deepinder SinghPaul Okunieff
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Oct 2, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mechteld C de JongTimothy M Pawlik
Jan 6, 2010·Japanese Journal of Clinical Oncology·Yuzuru Niibe, Kazushige Hayakawa
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Barbara Alicja Jereczek-FossaRoberto Orecchia
Jan 25, 2013·Frontiers in Oncology·Kamran A AhmedKenneth R Olivier
Oct 19, 2013·The Journal of Clinical Investigation·Michael C HaffnerSrinivasan Yegnasubramanian
Nov 12, 2013·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Mar 7, 2014·European Journal of Nuclear Medicine and Molecular Imaging·M PicchioN Di Muzio
Jun 13, 2014·Radiation Oncology·Karel DecaesteckerPiet Ost
Jun 28, 2014·Clinical & Experimental Metastasis·Abhineet UppalRalph R Weichselbaum
Oct 13, 2014·European Urology·Niccolò M Passoni, Thomas J Polascik
Apr 2, 2015·Nature·Gunes GundemG Steven Bova
May 23, 2015·Cell·Dan RobinsonArul M Chinnaiyan
Aug 13, 2015·World Journal of Clinical Oncology·Amalia Palacios-Eito, Sonia García-Cabezas
Sep 4, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A J Conde-MorenoJ Expósito-Hernández
May 1, 2016·International Journal of Radiation Oncology, Biology, Physics·Jonathan L MuldermansKenneth R Olivier
Nov 1, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A J Conde-MorenoC Ferrer-Albiach
Jun 6, 2017·The New England Journal of Medicine·Karim FizaziUNKNOWN LATITUDE Investigators
Jun 25, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paul J RoachAndrew M Scott
Dec 15, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Piet OstGert De Meerleer

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Citations

Dec 7, 2019·American Journal of Clinical Oncology·Gustavo A VianiFlavio S Guimarães
Sep 3, 2019·Frontiers in Oncology·Ewelina StelcerWiktoria Maria Suchorska
May 3, 2020·Nature Reviews. Urology·Yiannis PhilippouRichard J Bryant
Dec 15, 2020·Clinical Nuclear Medicine·Luke HilliarRobert Mansberg
Jul 14, 2020·International Journal of Radiation Oncology, Biology, Physics·Sarah BergaminGeorge Hruby
Nov 7, 2020·Clinical Nuclear Medicine·Luke HilliarRobert Mansberg
Mar 23, 2021·Radiation Oncology·Paul RogowskiMinglun Li
Sep 10, 2019·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C BourgierD Azria

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Methods Mentioned

BETA
imaging techniques
MDT
surgical resection
dissection

Clinical Trials Mentioned

NCT02680587
NCT02759783
NCT03569241
NCT02685397
NCT03361735
NCT01818986
NCT02816983
NCT02192788

Software Mentioned

PEACE
POPSTART

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