Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice

Drug Discoveries & Therapeutics
Chan Hum ParkTakako Yokozawa

Abstract

Oligonol is a phenolic product derived from lychee fruit extract containing catechin-type monomers and oligomers of proanthocyanidins, produced by a manufacturing process which converts polyphenol polymers into oligomers. These proanthocyanidins have been reported to exhibit beneficial bioactivities in many studies, and so oligonol, a rich source of polyphenol, is expected to show favorable effects on various chronic diseases. This article summarizes recent work whether oligonol has an ameliorative effect on diabetic indices and renal disorders associated with gluco-lipotoxicity-mediated oxidative stress, inflammation, and apoptosis in db/db mice with diabetes. Oligonol was able to improve diabetic indices, prevent the development of diabetic renal disease, and preserve renal cells and the renal morphological structure via the attenuation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-induced oxidative stress, inhibition of advanced glycation endproduct (AGE) generation, and prevention of apoptosis-induced cell death in db/db mice, being independent of changes in the body weight or serum glucose levels. The present study provides important evidence that oligonol exhibits a pleiotropic effect, representin...Continue Reading

References

Jan 1, 1991·The American Journal of Clinical Nutrition·E NikiK Sato
Aug 1, 1993·Antiviral Research·M NakayamaT Shimamura
Feb 1, 1996·Journal of Natural Products·E Haslam
Jun 1, 1997·The International Journal of Biochemistry & Cell Biology·P J Barnes
Nov 18, 1998·Archives of Internal Medicine·L C Winslow, D J Kroll
Oct 26, 2001·Biochemical and Biophysical Research Communications·S PalG Sa
Mar 20, 2002·Current Molecular Medicine·Y Yamamoto, R B Gaynor
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
May 9, 2003·American Journal of Physiology. Renal Physiology·Kumar SharmaStephen R Dunn
Oct 2, 2003·The Journal of Nutrition·Anton Rietveld, Sheila Wiseman
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiArthur J McCullough
Apr 13, 2004·Oncogene·Teiji Wada, Josef M Penninger
Aug 28, 2004·The Medical Clinics of North America·Preethi Srikanthan, Willa Hsueh
Dec 1, 2004·The Journal of Nutrition·Vanessa Crespy, Gary Williamson
Dec 29, 2004·Diabetes Research and Clinical Practice·Nessar Ahmed
Mar 11, 2005·FEBS Letters·Kelly JohnstonLinda Morgan
Oct 6, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kunitoshi IsekiUNKNOWN Patient Registration Committee of the Japanese Society for Dialysis Therapy
Feb 24, 2006·Toxicology and Applied Pharmacology·Anabela P Rolo, Carlos M Palmeira
May 5, 2006·Kidney International·C W ParkY Guan
Jul 13, 2006·The Journal of Pharmacology and Experimental Therapeutics·Noriko YamabeMujo Kim
Aug 22, 2006·The Journal of Nutrition·Pierre BratMarie Josèphe Amiot
Dec 23, 2006·Antioxidants & Redox Signaling·Takeshi Nishikawa, Eiichi Araki
Jun 8, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Eun-Hye JoKyung-Sun Kang
Dec 25, 2007·Experimental Biology and Medicine·Yashpal S KanwarFarhad R Danesh
Jan 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Su-Yen Goh, Mark E Cooper
Jan 29, 2008·Photochemistry and Photobiology·Joydeb Kumar KunduYoung-Joon Surh
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Peter J Jones, Krista A Varady
Sep 9, 2008·Reviews in Endocrine & Metabolic Disorders·K J Chang-ChenE Bernal-Mizrachi

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Citations

May 24, 2016·Nutrients·Roberto TestaAntonio Ceriello
Feb 13, 2016·Nutrition Research and Practice·Seul-Ki ParkOk Sarah Shin
Nov 24, 2018·Diabetes/metabolism Research and Reviews·Axel GuilbaudFrédéric J Tessier
Apr 16, 2020·International Journal of Molecular Sciences·Lucas Opazo-RíosJesús Egido
Sep 24, 2021·Critical Reviews in Food Science and Nutrition·Mamali DasSeyed Mohammad Nabavi
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yao ChenZhiyong He

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