Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality

Molecular Nutrition & Food Research
Yun-Ching ChangSue-Joan Chang

Abstract

Oligonol has been shown to moderate mitochondrial biogenesis, protein synthesis, and protein degradation in diabetic mice in a previous study. It is therefore hypothesized that oligonol alleviated sarcopenia by regulating pathways involved in protein turnover and mitochondrial quality. The 32-week-old senescence-accelerated mouse prone 8 (SAMP8) mice are fed with chow diet containing 200 mg kg-1 oligonol for 8 weeks. Oligonol supplementation increased skeletal muscle mass, cross-sectional areas, and grip strength in SAMP8 mice. Oligonol increased phosphorylation of AKT/mTOR/p70sk6, inhibited nuclear localization of FoxO3a and NFκB, and decreased transcription of MuRF-1 and MAFbx in skeletal muscle of SAMP8 mice. Downregulation of mitochondrial biogenesis genes (PGC-1α and Tfam) and mitochondrial fusion genes (Mfn2 and Opa1), loss of PINK1, overexpression of Atg13, LC3-II, and p62, and abundant accumulation of autophagosomes and lysosomes in skeletal muscle of SAMP8 mice are limited by oligonol. Furthermore, oligonol reduced expression of released cytochrome c and cleaved caspase-9 in skeletal muscle of SAMP8 mice. Regulating pathways involved in protein synthesis and degradation, mitochondrial biogenesis, mitochondrial fusion/f...Continue Reading

References

May 1, 1997·The Journal of Nutrition·I H Rosenberg
Jun 5, 2003·Physiological Genomics·Stephen WelleCharles A Thornton
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stewart H LeckerAlfred L Goldberg
Nov 13, 2004·The EMBO Journal·Marieke A G EssersBoudewijn M T Burgering
Jun 14, 2005·Pflügers Archiv : European journal of physiology·Samantha A WhitmanMichael P Godard
Jul 28, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Erik EdströmBrun Ulfhake
Sep 5, 2006·Mechanisms of Ageing and Development·Stephan ClavelBenoît Derijard
Nov 4, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hajime FujiiOkezie I Aruoma
Dec 7, 2007·Cell Metabolism·Cristina MammucariMarco Sandri
Nov 12, 2009·Experimental Gerontology·Stephanie Eva WohlgemuthChristiaan Leeuwenburgh
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Sep 8, 2010·Rejuvenation Research·Miaozong WuEric R Blough
Dec 24, 2010·Nature Reviews. Molecular Cell Biology·Richard J Youle, Derek P Narendra
Jan 12, 2011·Pflügers Archiv : European journal of physiology·Victoria C FolettaAaron P Russell
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
Jun 23, 2012·Cell Death and Differentiation·S ShaidI Dikic
Jun 30, 2012·Cell Death and Differentiation·G Ashrafi, T L Schwarz
Nov 17, 2012·Biological Chemistry·Riccardo CalvaniEmanuele Marzetti
Jul 31, 2013·Autophagy·Perrine Castets, Markus A Rüegg
Sep 25, 2015·Journal of Cachexia, Sarcopenia and Muscle·T Scott BowenVolker Adams
Nov 19, 2015·Journal of Cellular Physiology·Jingjing FanNing Chen
Nov 22, 2015·Pharmacological Reviews·Hagir B Suliman, Claude A Piantadosi
Jan 8, 2016·Nature·Laura García-PratPura Muñoz-Cánoves
Jan 19, 2016·Translation·Neethi Nandagopal, Philippe P Roux
Oct 19, 2016·Cell Death and Differentiation·E FiaccoL Latella
Jun 26, 2017·Biochemical and Biophysical Research Communications·Elvira P Leites, Vanessa A Morais

❮ Previous
Next ❯

Citations

Aug 29, 2020·Aging Cell·Courtney J Christian, Guy M Benian
Nov 5, 2020·The British Journal of Nutrition·Yasuyuki KobayashiRyoichi Yamaji
Feb 5, 2021·Mechanisms of Ageing and Development·Sergio DavinelliGiovanni Scapagnini
Dec 8, 2020·Food Science and Biotechnology·Changhee Kim, Jae-Kwan Hwang
May 6, 2021·Journal of Cachexia, Sarcopenia and Muscle·Wen-Qing XieYu-Sheng Li
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jeong Hun KimKeunyoung Kim
Oct 29, 2021·Molecular Nutrition & Food Research·Ji-Eun KimYoungji Han

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.