Oligonucleotide aptamers: potential novel molecules against viral hepatitis

Research in Pharmaceutical Sciences
Mina MirianHojjat Sadeghi-Aliabadi

Abstract

Viral hepatitis, as an international public health concern, seriously affects communities and health system. In recent years, great strides have been taken for development of new potential tools against viral hepatitis. Among these efforts, a valuable strategy introduced new molecules called "aptamers". Aptamers as potential alternatives for antibodies could be directed against any protein in infected cells and any components of viral particles. In this review, we will focus on recent advances in the diagnosis and treatment of viral hepatitis based on aptamer technology. In recent years, various types of aptamers including RNA and DNA were introduced against viral hepatitis. Some of these aptamers can be utilized for early and precise diagnosis of hepatitis infections and other group selected as therapeutic tools against viral targets. Designing diagnostic and therapeutic platforms based on aptamer technology is a promising approach in viral infections. The obtained aptamers in the recent years showed obvious potential for use as diagnostic and therapeutic tools against viral hepatitis. Although some modifications to increase the biostability and half-life of aptamers are underway, it seems these molecules will be a favorable s...Continue Reading

Citations

Mar 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mansoureh HaghighiAbbasali Palizban
Dec 6, 2017·Research in Pharmaceutical Sciences·Leila DarziMohammad Amin Tabatabaiefar
Jan 17, 2020·Current Pharmaceutical Design·Rosella CataldoEleonora Alfinito
Oct 3, 2018·Pharmaceuticals·Philisiwe Fortunate MolefeAbidemi Paul Kappo
May 22, 2019·Journal of Cellular Biochemistry·Shirin KouhpayehHossein Khanahmad
Jan 6, 2021·Molecular Biology Reports·Mina MirianHossein Khanahmad

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Methods Mentioned

BETA
exponential enrichment
biosensors
fluorescence microscopy
SELEX
ELISA
biosensor
transfection
PCR

Software Mentioned

ELASA

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