Oligonucleotide-based biosensors for in vitro diagnostics and environmental hazard detection

Analytical and Bioanalytical Chemistry
Il Young JungHyukjin Lee

Abstract

Oligonucleotide-based biosensors have drawn much attention because of their broad applications in in vitro diagnostics and environmental hazard detection. They are particularly of interest to many researchers because of their high specificity as well as excellent sensitivity. Recently, oligonucleotide-based biosensors have been used to achieve not only genetic detection of targets but also the detection of small molecules, peptides, and proteins. This has further broadened the applications of these sensors in the medical and health care industry. In this review, we highlight various examples of oligonucleotide-based biosensors for the detection of diseases, drugs, and environmentally hazardous chemicals. Each example is provided with detailed schematics of the detection mechanism in addition to the supporting experimental results. Furthermore, future perspectives and new challenges in oligonucleotide-based biosensors are discussed.

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Citations

Mar 16, 2017·World Journal of Biological Chemistry·Ferdinando Febbraio
Apr 4, 2017·Advanced Healthcare Materials·Il Young JungHyukjin Lee
Jan 29, 2020·Analytical and Bioanalytical Chemistry·Oleg L BodulevIvan Yu Sakharov
Feb 23, 2020·Current Medicinal Chemistry·Minmin ChangJunli Ren
May 4, 2021·Advanced Healthcare Materials·Anna HerrmannUwe Schedler

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